Literature DB >> 17898897

The type I fatty acid and polyketide synthases: a tale of two megasynthases.

Stuart Smith1, Shiou-Chuan Tsai.   

Abstract

This review chronicles the synergistic growth of the fields of fatty acid and polyketide synthesis over the last century. In both animal fatty acid synthases and modular polyketide synthases, similar catalytic elements are covalently linked in the same order in megasynthases. Whereas in fatty acid synthases the basic elements of the design remain immutable, guaranteeing the faithful production of saturated fatty acids, in the modular polyketide synthases, the potential of the basic design has been exploited to the full for the elaboration of a wide range of secondary metabolites of extraordinary structural diversity.

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Year:  2007        PMID： 17898897      PMCID： PMC2263081          DOI： 10.1039/b603600g

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  181 in total

Review 1.  Type I polyketide biosynthesis in bacteria (part B).

Authors:  B J Rawlings
Journal:  Nat Prod Rep       Date:  2001-06       Impact factor: 13.423

2.  High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.

Authors:  Helen M O'Hare; Abel Baerga-Ortiz; Bojana Popovic; Jonathan B Spencer; Peter F Leadlay
Journal:  Chem Biol       Date:  2006-03

3.  Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases.

Authors:  Grace F Liou; Janice Lau; David E Cane; Chaitan Khosla
Journal:  Biochemistry       Date:  2003-01-14       Impact factor: 3.162

4.  The structure of docking domains in modular polyketide synthases.

Authors:  R William Broadhurst; Daniel Nietlispach; Michael P Wheatcroft; Peter F Leadlay; Kira J Weissman
Journal:  Chem Biol       Date:  2003-08

5.  Effect of modification of the length and flexibility of the acyl carrier protein-thioesterase interdomain linker on functionality of the animal fatty acid synthase.

Authors:  Anil K Joshi; Andrzej Witkowski; Harvey A Berman; Lei Zhang; Stuart Smith
Journal:  Biochemistry       Date:  2005-03-15       Impact factor: 3.162

6.  Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry.

Authors:  Hui Hong; Antony N Appleyard; Alexandros P Siskos; Jose Garcia-Bernardo; James Staunton; Peter F Leadlay
Journal:  FEBS J       Date:  2005-05       Impact factor: 5.542

7.  THE ENZYMATIC SYNTHESIS OF FATTY ACIDS BY ALDOL CONDENSATION.

Authors:  R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1958-10-15       Impact factor: 11.205

8.  Engineered biosynthesis of a complete macrolactone in a heterologous host.

Authors:  C M Kao; L Katz; C Khosla
Journal:  Science       Date:  1994-07-22       Impact factor: 47.728

9.  Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase.

Authors:  C M Kao; R Pieper; D E Cane; C Khosla
Journal:  Biochemistry       Date:  1996-09-24       Impact factor: 3.162

10.  The effect of aromatic CoA esters on fatty acid synthetase: biosynthesis of omega-phenyl fatty acids.

Authors:  S Smith; A Stern
Journal:  Arch Biochem Biophys       Date:  1983-04-01       Impact factor: 4.013
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  106 in total

1.  Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain.

Authors:  Xun Guo; Tiangang Liu; Chiara R Valenzano; Zixin Deng; David E Cane
Journal:  J Am Chem Soc       Date:  2010-10-27       Impact factor: 15.419

2.  Biosynthesis: An HR-PKS stereo surprise.

Authors:  Ikuro Abe
Journal:  Nat Chem Biol       Date:  2012-03-16       Impact factor: 15.040

Review 3.  Structural classification and properties of ketoacyl synthases.

Authors:  Yingfei Chen; Erin E Kelly; Ryan P Masluk; Charles L Nelson; David C Cantu; Peter J Reilly
Journal:  Protein Sci       Date:  2011-10       Impact factor: 6.725

Review 4.  New insights into the formation of fungal aromatic polyketides.

Authors:  Jason M Crawford; Craig A Townsend
Journal:  Nat Rev Microbiol       Date:  2010-12       Impact factor: 60.633

5.  Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.

Authors:  Tonia J Buchholz; Christopher M Rath; Nicole B Lopanik; Noah P Gardner; Kristina Håkansson; David H Sherman
Journal:  Chem Biol       Date:  2010-10-29

6.  Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect".

Authors:  Jason M Crawford; Anna L Vagstad; Karen P Whitworth; Kenneth C Ehrlich; Craig A Townsend
Journal:  Chembiochem       Date:  2008-05-05       Impact factor: 3.164

7.  Crystal structure of the erythromycin polyketide synthase dehydratase.

Authors:  Adrian Keatinge-Clay
Journal:  J Mol Biol       Date:  2008-10-11       Impact factor: 5.469

8.  Probing the compatibility of type II ketosynthase-carrier protein partners.

Authors:  Andrew S Worthington; Gene H Hur; Jordan L Meier; Qian Cheng; Bradley S Moore; Michael D Burkart
Journal:  Chembiochem       Date:  2008-09-01       Impact factor: 3.164

9.  Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.

Authors:  Tonia J Buchholz; Todd W Geders; Frank E Bartley; Kevin A Reynolds; Janet L Smith; David H Sherman
Journal:  ACS Chem Biol       Date:  2009-01-16       Impact factor: 5.100

Review 10.  Structural analysis of protein-protein interactions in type I polyketide synthases.

Authors:  Wei Xu; Kangjian Qiao; Yi Tang
Journal:  Crit Rev Biochem Mol Biol       Date:  2012-12-19       Impact factor: 8.250
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