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Literature DB >> 17889366

The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.

Abstract

Based on the Tritope Model of the TCR [Cohn, M., 2005c. The Tritope Model for restrictive recognition of antigen by T-cells. I. What assumptions about structure are needed to explain function? Mol. Immunol. 42, 1419-1443], a set of functional and evolutionary problems surrounding restrictive recognition of antigen are discussed. These include the origin of allele-specific recognition, the selection pressures for polygeneism and polymorphism, the TCR signaling interactions, the centrality of effector T-helper (eTh)-dependence for activation, the role of haplotype exclusion, "nonclassical" MHC-elements, alloreactivity versus xenoreactivity, etc. Further, a set of observations believed to support the Standard Model are reinterpreted.

Entities: Gene

Mesh：

Substances：
Antigens

Year: 2007 PMID： 17889366 PMCID： PMC2104471 DOI： 10.1016/j.molimm.2006.02.033

Source DB: PubMed Journal: Mol Immunol ISSN： 0161-5890 Impact factor: 4.407

55 in total

10. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition.

Authors: J W Kappler; B Skidmore; J White; P Marrack
Journal: J Exp Med Date: 1981-05-01 Impact factor: 14.307

10 in total

The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.

Review 1. Selecting and maintaining a diverse T-cell repertoire.

Review 2. Tritope model of restrictive recognition by the TCR.

3. Distinguishing the tritope from the interaction antigen models.

4. The immune system: a weapon of mass destruction invented by evolution to even the odds during the war of the DNAs.

5. Killer cells reactive to altered-self antigens can also be alloreactive.

6. Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?

7. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.

Review 8. An alternative to current thinking about positive selection, negative selection and activation of T cells.

9. Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

10. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition.

1. Ten experiments that would make a difference in understanding immune mechanisms.

Review 2. An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition.

Review 3. What roles do regulatory T cells play in the control of the adaptive immune response?

4. What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?

Review 5. Signaling interactions predicted by the Tritope model of the TCR.

6. On the logic of restrictive recognition of peptide by the T-cell antigen receptor.

7. On the opposing views of the self-nonself discrimination by the immune system.

8. A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR.

9. The discussion with Jacques Miller: illustrating the limitations of pure empiricism.

10. Why rethink the structure-function relationships regulating TCR behavior?