Literature DB >> 20931295

On the logic of restrictive recognition of peptide by the T-cell antigen receptor.

Melvin Cohn1.   

Abstract

This essay provides an analysis of the inadequacy of the current view of restrictive recognition of peptide by the T-cell antigen receptor. A competing model is developed, and the experimental evidence for the prevailing model is reinterpreted in the new framework. The goal is to contrast the two models with respect to their consistency, coverage of the data, explanatory power, and predictability.

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Year:  2011        PMID： 20931295      PMCID： PMC3085606          DOI： 10.1007/s12026-010-8173-y

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  74 in total

1.  Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo.

Authors:  Nuno L Alves; Nicholas D Huntington; Jean-Jacques Mention; Odile Richard-Le Goff; James P Di Santo
Journal:  J Immunol       Date:  2010-05-03       Impact factor: 5.422

2.  Asymmetry in the recognition of antigen: self class II MHC and non-self class II MHC molecules by the same T-cell receptor.

Authors:  P Portoles; J M Rojo; C A Janeway
Journal:  J Mol Cell Immunol       Date:  1989

3.  Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

Authors:  Jung-Hyun Park; Stanley Adoro; Terry Guinter; Batu Erman; Amala S Alag; Marta Catalfamo; Motoko Y Kimura; Yongzhi Cui; Philip J Lucas; Ronald E Gress; Masato Kubo; Lothar Hennighausen; Lionel Feigenbaum; Alfred Singer
Journal:  Nat Immunol       Date:  2010-01-31       Impact factor: 25.606

4.  Positive and negative selection of an antigen receptor on T cells in transgenic mice.

Authors:  W C Sha; C A Nelson; R D Newberry; D M Kranz; J H Russell; D Y Loh
Journal:  Nature       Date:  1988-11-03       Impact factor: 49.962

Review 5.  The molecular basis of TCR germline bias for MHC is surprisingly simple.

Authors:  K Christopher Garcia; Jarrett J Adams; Dan Feng; Lauren K Ely
Journal:  Nat Immunol       Date:  2009-02       Impact factor: 25.606

6.  Cutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease.

Authors:  Gerald P Morris; Paul M Allen
Journal:  J Immunol       Date:  2009-06-01       Impact factor: 5.422

7.  Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides.

Authors:  Natalie A Bowerman; Leremy A Colf; K Christopher Garcia; David M Kranz
Journal:  J Biol Chem       Date:  2009-09-15       Impact factor: 5.157

8.  How the thymus designs antigen-specific and self-tolerant T cell receptor sequences.

Authors:  Andrej Kosmrlj; Abhishek K Jha; Eric S Huseby; Mehran Kardar; Arup K Chakraborty
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-22       Impact factor: 11.205

Review 9.  Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper.

Authors:  Ed Palmer; Dieter Naeher
Journal:  Nat Rev Immunol       Date:  2009-03       Impact factor: 53.106

10.  Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

Authors:  Travis Beddoe; Zhenjun Chen; Craig S Clements; Lauren K Ely; Simon R Bushell; Julian P Vivian; Lars Kjer-Nielsen; Siew Siew Pang; Michelle A Dunstone; Yu Chih Liu; Whitney A Macdonald; Matthew A Perugini; Matthew C J Wilce; Scott R Burrows; Anthony W Purcell; Tony Tiganis; Stephen P Bottomley; James McCluskey; Jamie Rossjohn
Journal:  Immunity       Date:  2009-05-21       Impact factor: 31.745
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  8 in total

1.  Ten experiments that would make a difference in understanding immune mechanisms.

Authors:  Melvin Cohn
Journal:  Cell Mol Life Sci       Date:  2011-11-01       Impact factor: 9.261

2.  Analysis of Paris meeting redefining the "self" of the immune system.

Authors:  Melvin Cohn
Journal:  Immunol Res       Date:  2015-05       Impact factor: 2.829

Review 3.  Learning from a contemporary history of immunology.

Authors:  Melvin Cohn
Journal:  Immunol Res       Date:  2017-06       Impact factor: 2.829

Review 4.  Rationalizing the path to a universal graft recipient.

Authors:  Melvin Cohn
Journal:  Immunol Res       Date:  2018-06       Impact factor: 2.829

Review 5.  Signaling interactions predicted by the Tritope model of the TCR.

Authors:  Melvin Cohn
Journal:  Immunol Res       Date:  2017-10       Impact factor: 2.829

Review 6.  A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells).

Authors:  Melvin Cohn
Journal:  Cell Mol Life Sci       Date:  2013-12-14       Impact factor: 9.261

Review 7.  An observation that illustrates most T cell receptor structure-function relationships.

Authors:  Melvin Cohn
Journal:  Immunol Res       Date:  2017-12       Impact factor: 2.829

Review 8.  Dissecting the two models of TCR structure-function relationships.

Authors:  Melvin Cohn
Journal:  Immunol Res       Date:  2016-08       Impact factor: 2.829
  8 in total

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