Literature DB >> 17888483

Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model.

Jin-Dong Ding1, John Lin, Brian E Mace, Rolf Herrmann, Patrick Sullivan, Catherine Bowes Rickman.   

Abstract

Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with Alzheimer's disease (AD) including extracellular deposits containing amyloid-beta (Abeta) peptides. Immunotherapy targeting the Abeta protein has been investigated as a potential treatment for AD. Here, we present the rationale for extending this approach to treat AMD. We tested an anti-Abeta antibody administered systemically in a mouse model of AMD. Histological and functional measurements in treated animals compared to controls showed that following immunotherapy, the amounts of Abeta in the retina and brain were decreased and the ERG deficits in the retina were attenuated. These data support the hypothesis that Abeta is a therapeutic target for AMD.

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Year:  2007        PMID： 17888483      PMCID： PMC2323206          DOI： 10.1016/j.visres.2007.07.025

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  39 in total

1.  Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.

Authors:  Volker Luibl; Jose M Isas; Rakez Kayed; Charles G Glabe; Ralf Langen; Jeannie Chen
Journal:  J Clin Invest       Date:  2006-02       Impact factor: 14.808

2.  Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q.

Authors:  M L Klein; D W Schultz; A Edwards; T C Matise; K Rust; C B Berselli; K Trzupek; R G Weleber; J Ott; M K Wirtz; T S Acott
Journal:  Arch Ophthalmol       Date:  1998-08

3.  Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment.

Authors:  B Piguet; J A Wells; I B Palmvang; R Wormald; I H Chisholm; A C Bird
Journal:  Br J Ophthalmol       Date:  1993-07       Impact factor: 4.638

4.  Complement factor H polymorphism and age-related macular degeneration.

Authors:  Albert O Edwards; Robert Ritter; Kenneth J Abel; Alisa Manning; Carolien Panhuysen; Lindsay A Farrer
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

5.  Complement factor H variant increases the risk of age-related macular degeneration.

Authors:  Jonathan L Haines; Michael A Hauser; Silke Schmidt; William K Scott; Lana M Olson; Paul Gallins; Kylee L Spencer; Shu Ying Kwan; Maher Noureddine; John R Gilbert; Nathalie Schnetz-Boutaud; Anita Agarwal; Eric A Postel; Margaret A Pericak-Vance
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

6.  Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.

Authors:  G Malek; L V Johnson; B E Mace; P Saloupis; D E Schmechel; D W Rickman; C A Toth; P M Sullivan; C Bowes Rickman
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-03       Impact factor: 11.205

7.  Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

Authors:  Donna M Wilcock; Amyn Rojiani; Arnon Rosenthal; Gil Levkowitz; Sangeetha Subbarao; Jennifer Alamed; David Wilson; Nedda Wilson; Melissa J Freeman; Marcia N Gordon; Dave Morgan
Journal:  J Neurosci       Date:  2004-07-07       Impact factor: 6.167

Review 8.  The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Authors:  John Hardy; Dennis J Selkoe
Journal:  Science       Date:  2002-07-19       Impact factor: 47.728

9.  Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas.

Authors:  Tzvete Dentchev; Ann H Milam; Virginia M-Y Lee; John Q Trojanowski; Joshua L Dunaief
Journal:  Mol Vis       Date:  2003-05-14       Impact factor: 2.367

10.  The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.

Authors:  Lincoln V Johnson; William P Leitner; Alexander J Rivest; Michelle K Staples; Monte J Radeke; Don H Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-20       Impact factor: 11.205
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  44 in total

1.  SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease.

Authors:  Kazuma Murakami; Nakaba Murata; Yoshihiro Noda; Shoichi Tahara; Takao Kaneko; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Kevin J Barnham; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
Journal:  J Biol Chem       Date:  2011-11-09       Impact factor: 5.157

Review 2.  Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.

Authors:  Catherine Bowes Rickman; Sina Farsiu; Cynthia A Toth; Mikael Klingeborn
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-12-13       Impact factor: 4.799

3.  Iron increases APP translation and amyloid-beta production in the retina.

Authors:  Lucie Y Guo; Oleg Alekseev; Yafeng Li; Ying Song; Joshua L Dunaief
Journal:  Exp Eye Res       Date:  2014-10-16       Impact factor: 3.467

Review 4.  Therapeutic Options Under Development for Nonneovascular Age-Related Macular Degeneration and Geographic Atrophy.

Authors:  Joon-Bom Kim; Eleonora M Lad
Journal:  Drugs Aging       Date:  2020-12-23       Impact factor: 3.923

Review 5.  At the interface of sensory and motor dysfunctions and Alzheimer's disease.

Authors:  Mark W Albers; Grover C Gilmore; Jeffrey Kaye; Claire Murphy; Arthur Wingfield; David A Bennett; Adam L Boxer; Aron S Buchman; Karen J Cruickshanks; Davangere P Devanand; Charles J Duffy; Christine M Gall; George A Gates; Ann-Charlotte Granholm; Takao Hensch; Roee Holtzer; Bradley T Hyman; Frank R Lin; Ann C McKee; John C Morris; Ronald C Petersen; Lisa C Silbert; Robert G Struble; John Q Trojanowski; Joe Verghese; Donald A Wilson; Shunbin Xu; Li I Zhang
Journal:  Alzheimers Dement       Date:  2014-07-09       Impact factor: 21.566

Review 6.  The proteomics of drusen.

Authors:  John W Crabb
Journal:  Cold Spring Harb Perspect Med       Date:  2014-05-05       Impact factor: 6.915

Review 7.  Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer's disease.

Authors:  T M Shah; S M Gupta; P Chatterjee; M Campbell; R N Martins
Journal:  Mol Psychiatry       Date:  2017-01-17       Impact factor: 15.992

8.  Plasma levels of amyloid beta and other proinflammatory mediators in patients with age-related macular degeneration.

Authors:  Robyn Guymer; Tania Cipriani; Kay D Rittenhouse; Lyndell Lim; Liubov D Robman; Wenlin Li; Wenlian Wang; Shibing Deng; Poulabi Banerjee
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-03-07       Impact factor: 3.117

9.  Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways.

Authors:  Mark W Logue; Matthew Schu; Badri N Vardarajan; John Farrell; Kathryn L Lunetta; Gyungah Jun; Clinton T Baldwin; Margaret M Deangelis; Lindsay A Farrer
Journal:  Neurobiol Aging       Date:  2013-12-19       Impact factor: 4.673

10.  Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease.

Authors:  Allison Ning; Jing Cui; Eleanor To; Karen Hsiao Ashe; Joanne Matsubara
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-06-19       Impact factor: 4.799
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