| Literature DB >> 25022540 |
Mark W Albers1, Grover C Gilmore2, Jeffrey Kaye3, Claire Murphy4, Arthur Wingfield5, David A Bennett6, Adam L Boxer7, Aron S Buchman6, Karen J Cruickshanks8, Davangere P Devanand9, Charles J Duffy10, Christine M Gall11, George A Gates12, Ann-Charlotte Granholm13, Takao Hensch14, Roee Holtzer15, Bradley T Hyman16, Frank R Lin17, Ann C McKee18, John C Morris19, Ronald C Petersen20, Lisa C Silbert3, Robert G Struble21, John Q Trojanowski22, Joe Verghese15, Donald A Wilson23, Shunbin Xu6, Li I Zhang24.
Abstract
Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled "Sensory and Motor Dysfunctions in Aging and AD." The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses.Entities:
Keywords: Aging; Alzheimer's disease; Auditory function; Motor; Olfaction; Sensory; Vision
Mesh：
Year: 2014 PMID： 25022540 PMCID： PMC4287457 DOI： 10.1016/j.jalz.2014.04.514
Source DB: PubMed Journal: Alzheimers Dement ISSN： 1552-5260 Impact factor: 21.566