RATIONALE: It remains unclear whether premature birth, in the absence of neonatal respiratory disease, results in abnormal growth and development of the lung. We previously reported that a group of healthy infants born at 32-34 weeks' gestation and without respiratory complications had decreased forced expiratory flows and normal forced vital capacities at 2 months of age. OBJECTIVES: Our current study evaluated whether these healthy infants born prematurely exhibited improvement or "catch-up" in their lung function during the second year of life. METHODS: Longitudinal measurements of forced expiratory flows by the raised volume rapid thoracic compression technique were obtained in the first and the second years of life for infants born prematurely at 32.7 (range, 30-34) weeks' gestation (n = 26) and infants born at full term (n = 24). MEASUREMENTS AND MAIN RESULTS: Healthy infants born prematurely demonstrate decreased forced expiratory flows and normal forced vital capacities in the first and second years of life. In addition, the increases in lung function with growth were similar to full-term infants. CONCLUSIONS: Persistently reduced flows in the presence of normal forced vital capacity and the absence of catch-up growth in airway function suggest that premature birth is associated with altered lung development.
RATIONALE: It remains unclear whether premature birth, in the absence of neonatal respiratory disease, results in abnormal growth and development of the lung. We previously reported that a group of healthy infants born at 32-34 weeks' gestation and without respiratory complications had decreased forced expiratory flows and normal forced vital capacities at 2 months of age. OBJECTIVES: Our current study evaluated whether these healthy infants born prematurely exhibited improvement or "catch-up" in their lung function during the second year of life. METHODS: Longitudinal measurements of forced expiratory flows by the raised volume rapid thoracic compression technique were obtained in the first and the second years of life for infants born prematurely at 32.7 (range, 30-34) weeks' gestation (n = 26) and infants born at full term (n = 24). MEASUREMENTS AND MAIN RESULTS: Healthy infants born prematurely demonstrate decreased forced expiratory flows and normal forced vital capacities in the first and second years of life. In addition, the increases in lung function with growth were similar to full-term infants. CONCLUSIONS: Persistently reduced flows in the presence of normal forced vital capacity and the absence of catch-up growth in airway function suggest that premature birth is associated with altered lung development.
Authors: M Jones; R Castile; S Davis; J Kisling; D Filbrun; R Flucke; A Goldstein; C Emsley; W Ambrosius; R S Tepper Journal: Am J Respir Crit Care Med Date: 2000-02 Impact factor: 21.405
Authors: S Lum; A F Hoo; C Dezateux; I Goetz; A Wade; L DeRooy; K Costeloe; J Stocks Journal: Am J Respir Crit Care Med Date: 2001-12-01 Impact factor: 21.405
Authors: Ah-Fong Hoo; Carol Dezateux; John P Hanrahan; Tim J Cole; Robert S Tepper; Janet Stocks Journal: Am J Respir Crit Care Med Date: 2002-04-15 Impact factor: 21.405
Authors: E E Sarria; R Mattiello; L Rao; C J Tiller; B Poindexter; K E Applegate; J Granroth-Cook; C Denski; J Nguyen; Z Yu; E Hoffman; R S Tepper Journal: Eur Respir J Date: 2011-10-17 Impact factor: 16.671
Authors: Karen M McDowell; Alan H Jobe; Matthew Fenchel; William D Hardie; Tate Gisslen; Lisa R Young; Claire A Chougnet; Stephanie D Davis; Suhas G Kallapur Journal: Ann Am Thorac Soc Date: 2016-06
Authors: Joseph Fawke; Sooky Lum; Jane Kirkby; Enid Hennessy; Neil Marlow; Victoria Rowell; Sue Thomas; Janet Stocks Journal: Am J Respir Crit Care Med Date: 2010-04-08 Impact factor: 21.405
Authors: Ryan Lam; Diane Schilling; Brian Scottoline; Astrid Platteau; Meike Niederhausen; Kelli C Lund; Robert L Schelonka; Kelvin D MacDonald; Cindy T McEvoy Journal: J Pediatr Date: 2019-09-10 Impact factor: 4.406