J Ryan Martin1, Anne Wold, Hugh S Taylor. 1. Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
Abstract
OBJECTIVE: To describe an unusual presentation of ring chromosome 12, which manifested as severe azoospermia, resulting in male infertility. DESIGN: Case report. SETTING: In vitro fertilization center at a tertiary care hospital. PATIENT(S): A 27-year-old man diagnosed with unexplained azoospermia and ring chromosome 12 abnormality during a workup for primary infertility. INTERVENTION(S): In vitro fertilization with preimplantation genetic diagnosis. MAIN OUTCOME MEASURE(S): To confirm the importance of obtaining karyotypes in individuals with severe oligospermia. RESULT(S): Full-term pregnancy after IVF using donor sperm. CONCLUSION(S): Severe oligospermia and male infertility should be included in the spectrum of findings found in ring chromosome 12.
OBJECTIVE: To describe an unusual presentation of ring chromosome 12, which manifested as severe azoospermia, resulting in male infertility. DESIGN: Case report. SETTING: In vitro fertilization center at a tertiary care hospital. PATIENT(S): A 27-year-old man diagnosed with unexplained azoospermia and ring chromosome 12 abnormality during a workup for primary infertility. INTERVENTION(S): In vitro fertilization with preimplantation genetic diagnosis. MAIN OUTCOME MEASURE(S): To confirm the importance of obtaining karyotypes in individuals with severe oligospermia. RESULT(S): Full-term pregnancy after IVF using donor sperm. CONCLUSION(S): Severe oligospermia and male infertility should be included in the spectrum of findings found in ring chromosome 12.