Literature DB >> 17876006

Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis.

Sean T Byrne1, Peihua Gu, Jiangbing Zhou, Steven M Denkin, Curtis Chong, David Sullivan, Jun O Liu, Ying Zhang.   

Abstract

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 microg/ml and 0.13 microg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

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Year:  2007        PMID： 17876006      PMCID： PMC2168016          DOI： 10.1128/AAC.00753-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

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Authors:  J L Sebat; A J Paszczynski; M S Cortese; R L Crawford
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Journal:  J Antimicrob Chemother       Date:  2006-09-01       Impact factor: 5.790

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  8 in total
  12 in total

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5.  Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

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Review 6.  Targeting persisters for tuberculosis control.

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7.  The effects of sodium diethyldithiocarbamate in fibroblasts V79 cells in relation to cytotoxicity, antioxidative enzymes, glutathione, and apoptosis.

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9.  Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.

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10.  Poly[μ2-aqua-aqua-[μ3-N-butyl-N-(2-hy-droxy-ethyl)di-thio-carbamato-κ(3) O,O':S]sodium].

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