| Literature DB >> 16816845 |
Curtis R Chong1, Xiaochun Chen, Lirong Shi, Jun O Liu, David J Sullivan.
Abstract
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery we created a library of 2,687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.Entities:
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Year: 2006 PMID： 16816845 DOI： 10.1038/nchembio806
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040