Literature DB >> 22615274

Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

Yasuhiro Horita1, Takemasa Takii, Tetsuya Yagi, Kenji Ogawa, Nagatoshi Fujiwara, Emi Inagaki, Laurent Kremer, Yasuo Sato, Ryuji Kuroishi, Yoosa Lee, Toshiaki Makino, Hajime Mizukami, Tomohiro Hasegawa, Ryuji Yamamoto, Kikuo Onozaki.   

Abstract

The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.

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Year:  2012        PMID： 22615274      PMCID： PMC3421551          DOI： 10.1128/AAC.06445-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

1.  Metal chelates and antitubercular activity. III. p-Aminosalicylic acid: chelate vs. complex.

Authors:  W O FOYE; R N DUVALL
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1958-04

2.  Metal chelates and antitubercular activity. II. p-Aminosalicylic acid.

Authors:  W O FOYE
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1955-07

3.  [Treatment of chronic alcoholism with a sensitizing drug].

Authors:  H ZAJACZKOWSKI
Journal:  Pol Tyg Lek (Wars)       Date:  1949-04-18

4.  Evidence for the bacterial origin of genes encoding fermentation enzymes of the amitochondriate protozoan parasite Entamoeba histolytica.

Authors:  B Rosenthal; Z Mai; D Caplivski; S Ghosh; H de la Vega; T Graf; J Samuelson
Journal:  J Bacteriol       Date:  1997-06       Impact factor: 3.490

5.  Disulfiram inhibits the in vitro growth of methicillin-resistant staphylococcus aureus.

Authors:  M Phillips; G Malloy; D Nedunchezian; A Lukrec; R G Howard
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

6.  In vitro antimicrobial activity of diethyldithiocarbamate and dimethyldithiocarbamate against methicillin-resistant Staphylococcus.

Authors:  E H Taylor; E M Walker; M Bartelt; S Day; A A Pappas
Journal:  Ann Clin Lab Sci       Date:  1987 May-Jun       Impact factor: 1.256

7.  Antimalarial activity of diethyldithiocarbamate. Potentiation by copper.

Authors:  S R Meshnick; M D Scott; B Lubin; A Ranz; J W Eaton
Journal:  Biochem Pharmacol       Date:  1990-07-15       Impact factor: 5.858

8.  Activation of the pro-drug ethionamide is regulated in mycobacteria.

Authors:  A R Baulard; J C Betts; J Engohang-Ndong; S Quan; R A McAdam; P J Brennan; C Locht; G S Besra
Journal:  J Biol Chem       Date:  2000-09-08       Impact factor: 5.157

9.  Metal chelates and antitubercular activity. I. o-Hydroxyazo naphthols and phenanthrols.

Authors:  W O FOYE; J G JEFFREY
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1955-05

Review 10.  Relevance of animal models for understanding mammalian copper homeostasis.

Authors:  Willianne I M Vonk; Cisca Wijmenga; Bart van de Sluis
Journal:  Am J Clin Nutr       Date:  2008-09       Impact factor: 7.045
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  15 in total

1.  The Repurposed Drug Disulfiram Inhibits Urease and Aldehyde Dehydrogenase and Prevents In Vitro Growth of the Oomycete Pythium insidiosum.

Authors:  Theerapong Krajaejun; Tassanee Lohnoo; Wanta Yingyong; Thidarat Rujirawat; Yothin Kumsang; Passara Jongkhajornpong; Sirin Theerawatanasirikul; Weerayuth Kittichotirat; Onrapak Reamtong; Hanna Yolanda
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

2.  Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.

Authors:  Emina Jukic; Michael Blatzer; Wilfried Posch; Marion Steger; Ulrike Binder; Cornelia Lass-Flörl; Doris Wilflingseder
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

3.  Copper complexation screen reveals compounds with potent antibiotic properties against methicillin-resistant Staphylococcus aureus.

Authors:  Mehri Haeili; Casey Moore; Christopher J C Davis; James B Cochran; Santosh Shah; Tej B Shrestha; Yaofang Zhang; Stefan H Bossmann; William H Benjamin; Olaf Kutsch; Frank Wolschendorf
Journal:  Antimicrob Agents Chemother       Date:  2014-04-21       Impact factor: 5.191

4.  Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner.

Authors:  Alex G Dalecki; Mehri Haeili; Santosh Shah; Alexander Speer; Michael Niederweis; Olaf Kutsch; Frank Wolschendorf
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

5.  Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases.

Authors:  Marco M Custodio; Jennifer Sparks; Timothy E Long
Journal:  Antiinfect Agents       Date:  2022-04-27

6.  Disulfiram blocked cell entry of SARS-CoV-2 via inhibiting the interaction of spike protein and ACE2.

Authors:  Hsiao-Fan Chen; Po-Ren Hsueh; Yen-Yi Liu; Yeh Chen; Sui-Yuan Chang; Wei-Jan Wang; Chen-Shiou Wu; Ya-Min Tsai; Yu-Shu Liu; Wen-Chi Su; Yu-Chi Chou; Mien-Chie Hung
Journal:  Am J Cancer Res       Date:  2022-07-15       Impact factor: 5.942

7.  Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions.

Authors:  Alex G Peniche; Adam R Renslo; Peter C Melby; Bruno L Travi
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191

8.  Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay.

Authors:  Juan D Guzman; Dimitrios Evangelopoulos; Antima Gupta; Kristian Birchall; Solomon Mwaigwisya; Barbara Saxty; Timothy D McHugh; Simon Gibbons; John Malkinson; Sanjib Bhakta
Journal:  BMJ Open       Date:  2013-06-20       Impact factor: 2.692

Review 9.  From Genome to Drugs: New Approaches in Antimicrobial Discovery.

Authors:  Federico Serral; Florencia A Castello; Ezequiel J Sosa; Agustín M Pardo; Miranda Clara Palumbo; Carlos Modenutti; María Mercedes Palomino; Alberto Lazarowski; Jerónimo Auzmendi; Pablo Ivan P Ramos; Marisa F Nicolás; Adrián G Turjanski; Marcelo A Martí; Darío Fernández Do Porto
Journal:  Front Pharmacol       Date:  2021-06-09       Impact factor: 5.810

10.  Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis.

Authors:  Hagit Bar-Yosef; Nora Vivanco Gonzalez; Shay Ben-Aroya; Stephen J Kron; Daniel Kornitzer
Journal:  Sci Rep       Date:  2017-07-18       Impact factor: 4.379
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