Literature DB >> 17873888

Speed-mapping quantitative trait loci using microarrays.

Chao-Qiang Lai1, Jeff Leips, Wei Zou, Jessica F Roberts, Kurt R Wollenberg, Laurence D Parnell, Zhao-Bang Zeng, Jose M Ordovas, Trudy F C Mackay.   

Abstract

We developed a rapid, economical method for high-resolution quantitative trait locus (QTL) mapping using microarrays for selective genotyping of pooled DNA samples. We generated 21,207 F2 flies from two inbred Drosophila melanogaster strains with known QTLs affecting lifespan, and hybridized DNA pools of young and old flies to microarrays. We used changes of gene frequency of 2,326 single-feature polymorphisms (SFPs) to map previously identified and additional QTLs affecting lifespan.

Entities:  

Mesh：

Year:  2007        PMID： 17873888     DOI： 10.1038/nmeth1084

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  29 in total

1.  Pleiotropy of segregating genetic variants that affect honey bee worker life expectancy.

Authors:  Luke R Dixon; Michelle R McQuage; Ellen J Lonon; Dominique Buehler; Oumar Seck; Olav Rueppell
Journal:  Exp Gerontol       Date:  2012-06-01       Impact factor: 4.032

2.  A test for selection employing quantitative trait locus and mutation accumulation data.

Authors:  Daniel P Rice; Jeffrey P Townsend
Journal:  Genetics       Date:  2012-01-31       Impact factor: 4.562

3.  Parent-independent genotyping for constructing an ultrahigh-density linkage map based on population sequencing.

Authors:  Weibo Xie; Qi Feng; Huihui Yu; Xuehui Huang; Qiang Zhao; Yongzhong Xing; Sibin Yu; Bin Han; Qifa Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-24       Impact factor: 11.205

Review 4.  The genetics of quantitative traits: challenges and prospects.

Authors:  Trudy F C Mackay; Eric A Stone; Julien F Ayroles
Journal:  Nat Rev Genet       Date:  2009-08       Impact factor: 53.242

5.  Multiplexed shotgun genotyping for rapid and efficient genetic mapping.

Authors:  Peter Andolfatto; Dan Davison; Deniz Erezyilmaz; Tina T Hu; Joshua Mast; Tomoko Sunayama-Morita; David L Stern
Journal:  Genome Res       Date:  2011-01-13       Impact factor: 9.043

Review 6.  Using next-generation sequencing to isolate mutant genes from forward genetic screens.

Authors:  Korbinian Schneeberger
Journal:  Nat Rev Genet       Date:  2014-08-20       Impact factor: 53.242

7.  Dissection of genetically complex traits with extremely large pools of yeast segregants.

Authors:  Ian M Ehrenreich; Noorossadat Torabi; Yue Jia; Jonathan Kent; Stephen Martis; Joshua A Shapiro; David Gresham; Amy A Caudy; Leonid Kruglyak
Journal:  Nature       Date:  2010-04-15       Impact factor: 49.962

8.  High-throughput marker discovery in melon using a self-designed oligo microarray.

Authors:  Ron Ophir; Ravit Eshed; Rotem Harel-Beja; Galil Tzuri; Vitaly Portnoy; Yoseph Burger; Shai Uliel; Nurit Katzir; Amir Sherman
Journal:  BMC Genomics       Date:  2010-04-28       Impact factor: 3.969

9.  Massively parallel resequencing of the isogenic Drosophila melanogaster strain w(1118); iso-2; iso-3 identifies hotspots for mutations in sensory perception genes.

Authors:  Adrian E Platts; Susan J Land; Lang Chen; Grier P Page; Parsa Rasouli; Luan Wang; Xiangyi Lu; Douglas M Ruden
Journal:  Fly (Austin)       Date:  2009-07-23       Impact factor: 2.160

Review 10.  Integrating evolutionary and molecular genetics of aging.

Authors:  Thomas Flatt; Paul S Schmidt
Journal:  Biochim Biophys Acta       Date:  2009-07-18
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