| Literature DB >> 1783389 |
D Schlessinger1, R D Little, D Freije, F Abidi, I Zucchi, G Porta, G Pilia, R Nagaraja, S K Johnson, J Y Yoon, A Srivastava, J Kere, G Palmieri, A Ciccodicola, V Montanaro, G Romano, A Casamassimi, M D'Urso.
Abstract
Yeast artificial chromosomes (YACs) have recently provided a potential route to long-range coverage of complex genomes in contiguous cloned DNA. In a pilot project for 50 Mb (1.5% of the human genome), a variety of techniques have been applied to assemble Xq24-q28 YAC contigs up to 8 Mb in length and assess their quality. The results indicate the relative strength of several approaches and support the adequacy of YAC-based methods for mapping the human genome.Entities:
Mesh:
Year: 1991 PMID: 1783389 DOI: 10.1016/0888-7543(91)90001-u
Source DB: PubMed Journal: Genomics ISSN: 0888-7543 Impact factor: 5.736