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Literature DB >> 17827032

Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry.

Markus Stoeckli¹, Dieter Staab, Alain Schweitzer, James Gardiner, Dieter Seebach.

Abstract

Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a beta-peptide and an alpha-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the alpha-peptide control was observed at 1 h post-dose, while retention of the beta-peptide was observed for longer than 24 h post-dose.

Entities: Gene Species

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Year: 2007 PMID： 17827032 DOI： 10.1016/j.jasms.2007.08.005

Source DB: PubMed Journal: J Am Soc Mass Spectrom ISSN： 1044-0305 Impact factor: 3.109

9 in total

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2. Molecular profiling of experimental Parkinson's disease: direct analysis of peptides and proteins on brain tissue sections by MALDI mass spectrometry.

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4. Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry.

Authors: Sheerin Khatib-Shahidi; Malin Andersson; Jennifer L Herman; Todd A Gillespie; Richard M Caprioli
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Review 5. The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components.

Authors: Dieter Seebach; Albert K Beck; Daniel J Bierbaum
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6. Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS.

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7. Beta(2)/beta(3)-di- and alpha/beta(3)-tetrapeptide derivatives as potent agonists at somatostatin sst(4) receptors.

Authors: Caroline Nunn; Magnus Rueping; Daniel Langenegger; Edi Schuepbach; Thierry Kimmerlin; Peter Micuch; Konstanze Hurth; Dieter Seebach; Daniel Hoyer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2003-01-24 Impact factor: 3.000

8. Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry.

Authors: Markus Stoeckli; Dieter Staab; Matthias Staufenbiel; Karl-Heinz Wiederhold; Luca Signor
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9. ADME investigations of unnatural peptides: distribution of a 14C-labeled beta 3-octaarginine in rats.

Authors: H Markus Weiss; Bernard Wirz; Alain Schweitzer; René Amstutz; Maria I Rodriguez Perez; Hendrik Andres; Yves Metz; James Gardiner; Dieter Seebach
Journal: Chem Biodivers Date: 2007-07 Impact factor: 2.408

9 in total

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3. High-speed MALDI-TOF imaging mass spectrometry: rapid ion image acquisition and considerations for next generation instrumentation.

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4. Imaging of phospholipids in formalin fixed rat brain sections by matrix assisted laser desorption/ionization mass spectrometry.

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5. Multimodal mass spectrometric imaging of small molecules reveals distinct spatio-molecular signatures in differentially metastatic breast tumor models.

Authors: Erika R Amstalden van Hove; Tiffany R Blackwell; Ivo Klinkert; Gert B Eijkel; Ron M A Heeren; Kristine Glunde
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