OBJECTIVE: The purpose of this study was to evaluate potential associations between vascular endothelial growth factor (VEGF) gene polymorphisms and preeclampsia. STUDY DESIGN: One hundred ten patients with preeclampsia and 209 healthy pregnant control subjects were enrolled in the study. After peripheral blood was obtained from all women and the genomic DNA was isolated, we genotyped +936C/T polymorphisms in the 3'-untranslated region of the VEGF gene, using polymerase chain reaction and restriction fragment length polymorphism techniques. RESULTS: The distribution of genotypes of the +936C/T polymorphism was significantly different between women with preeclampsia and the control group (P < .001). Carriage of the +936T allele was significantly more frequent in preeclamptic patients than in control subjects (odds ratio, 2.06; 95% CI,1.38-3.08). Logistic regression analysis on VEGF genotype and clinical parameters such as age, educational status, body mass index, and neonatal gender showed carriage of the 936T allele to be significantly more frequent in preeclamptic patients than in control subjects (adjusted odds ratio, 2.23; 95% CI, 1.46-3.42). CONCLUSION: Carriage of the +936T allele of the VEGF gene may be associated with increased susceptibility to the development of preeclampsia and may be an independent risk factor for preeclampsia.
OBJECTIVE: The purpose of this study was to evaluate potential associations between vascular endothelial growth factor (VEGF) gene polymorphisms and preeclampsia. STUDY DESIGN: One hundred ten patients with preeclampsia and 209 healthy pregnant control subjects were enrolled in the study. After peripheral blood was obtained from all women and the genomic DNA was isolated, we genotyped +936C/T polymorphisms in the 3'-untranslated region of the VEGF gene, using polymerase chain reaction and restriction fragment length polymorphism techniques. RESULTS: The distribution of genotypes of the +936C/T polymorphism was significantly different between women with preeclampsia and the control group (P < .001). Carriage of the +936T allele was significantly more frequent in preeclamptic patients than in control subjects (odds ratio, 2.06; 95% CI,1.38-3.08). Logistic regression analysis on VEGF genotype and clinical parameters such as age, educational status, body mass index, and neonatal gender showed carriage of the 936T allele to be significantly more frequent in preeclamptic patients than in control subjects (adjusted odds ratio, 2.23; 95% CI, 1.46-3.42). CONCLUSION: Carriage of the +936T allele of the VEGF gene may be associated with increased susceptibility to the development of preeclampsia and may be an independent risk factor for preeclampsia.
Authors: Melissa D Amosco; Van Anthony M Villar; Justin Michael A Naniong; Lara Marie G David-Bustamante; Pedro A Jose; Cynthia P Palmes-Saloma Journal: Clin Exp Hypertens Date: 2016-09-26 Impact factor: 1.749
Authors: Bryan P Schneider; Molin Wang; Milan Radovich; George W Sledge; Sunil Badve; Ann Thor; David A Flockhart; Bradley Hancock; Nancy Davidson; Julie Gralow; Maura Dickler; Edith A Perez; Melody Cobleigh; Tamara Shenkier; Susan Edgerton; Kathy D Miller Journal: J Clin Oncol Date: 2008-10-01 Impact factor: 44.544
Authors: Francisco J Valenzuela; Alejandra Pérez-Sepúlveda; María J Torres; Paula Correa; Gabriela M Repetto; Sebastián E Illanes Journal: J Pregnancy Date: 2011-12-01
Authors: Feriha Fatima Khidri; Yar Muhammad Waryah; Faiza Kamran Ali; Hina Shaikh; Ikram Din Ujjan; Ali Muhammad Waryah Journal: BMC Med Genet Date: 2019-10-23 Impact factor: 2.103
Authors: José Pacheco-Romero; Oscar Acosta; Doris Huerta; Santiago Cabrera; Marlene Vargas; Pedro Mascaro; Moisés Huamán; José Sandoval; Rudy López; Julio Mateus; Enrique Gil; Enrique Guevara; Nitza Butrica; Diana Catari; David Bellido; Gina Custodio; Andrea Naranjo Journal: Colomb Med (Cali) Date: 2021-02-26
Authors: Hameed M Hamid; Sana E Abdalla; Mohamed Sidig; Ishag Adam; Hamdan Z Hamdan Journal: Mol Genet Genomic Med Date: 2020-01-14 Impact factor: 2.183