Qian Tang1,2, Ling Wang3, Renmei Cai4, Lu Zhang1,2, Xiaoxiao Zhang3, Xuemei Liu3, Shiguo Liu1,2. 1. Medical Genetic Department, the Affiliated Hospital of Qingdao University, Qingdao, China. 2. Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, China. 3. Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, China. 4. Prenatal Diagnosis Center, Qingdao Municipal Hospital, Qingdao, China.
Abstract
BACKGROUND: To assess the relationship between MOV10 rs2932538 polymorphism and susceptibility to preeclampsia (PE) in the Chinese Han population and to investigate whether the placental expression of MOV10 have association with PE. METHODS: We enrolled 1021 pregnant women with PE and 1594 normotensive pregnant women to analyze genotyping of MOV10 rs2932538. Clinical data and related test results of all subjects were collected and analyzed. For volunteers providing placentas, real-time PCR, Western blot, and immunohistochemistry were applied to assess the expression level of MOV10. RESULTS: There was significant statistical difference between preeclamptic patients and healthy subjects in genotype distributions and alleles. The frequencies of genotypes TT+CT were significantly associated with the increased risk of preeclampsia. Besides, T alleles were found to be related to a higher risk of PE. Significant statistical difference was also observed on distributions of genotype in PE without/with severe features group compared or early onset/late onset versus controls. The placental expression of MOV10 was lower in preeclamptic women, however, no relationship was found between MOV10 expression level and MOV10 rs2932538 genotypes. CONCLUSION: This study suggests that MOV10 rs2932538 polymorphism may be associated with PE susceptibility in the Chinese Han population. The placental expression of MOV10 decrease in PE but have no relationship with rs2932538 polymorphism.
BACKGROUND: To assess the relationship between MOV10rs2932538 polymorphism and susceptibility to preeclampsia (PE) in the Chinese Han population and to investigate whether the placental expression of MOV10 have association with PE. METHODS: We enrolled 1021 pregnant women with PE and 1594 normotensive pregnant women to analyze genotyping of MOV10rs2932538. Clinical data and related test results of all subjects were collected and analyzed. For volunteers providing placentas, real-time PCR, Western blot, and immunohistochemistry were applied to assess the expression level of MOV10. RESULTS: There was significant statistical difference between preeclamptic patients and healthy subjects in genotype distributions and alleles. The frequencies of genotypes TT+CT were significantly associated with the increased risk of preeclampsia. Besides, T alleles were found to be related to a higher risk of PE. Significant statistical difference was also observed on distributions of genotype in PE without/with severe features group compared or early onset/late onset versus controls. The placental expression of MOV10 was lower in preeclamptic women, however, no relationship was found between MOV10 expression level and MOV10rs2932538 genotypes. CONCLUSION: This study suggests that MOV10rs2932538 polymorphism may be associated with PE susceptibility in the Chinese Han population. The placental expression of MOV10 decrease in PE but have no relationship with rs2932538 polymorphism.
Authors: Augusta M A Lachmeijer; Guustaaf A Dekker; Gerard Pals; Jan G Aarnoudse; Leo P ten Kate; Reynir Arngrímsson Journal: Eur J Obstet Gynecol Reprod Biol Date: 2002-11-15 Impact factor: 2.435
Authors: Ben W J Mol; Claire T Roberts; Shakila Thangaratinam; Laura A Magee; Christianne J M de Groot; G Justus Hofmeyr Journal: Lancet Date: 2015-09-02 Impact factor: 79.321