BACKGROUND: Very long chain omega-3 fatty acids (w-3 PUFA) intake and fish consumption have been suggested as protective factors against neuropsychiatric disorders but there is scarcity of large cohort studies assessing this association. AIM OF THE STUDY: To assess the association between w-3-PUFA intake and fish consumption and mental disorders. METHODS: A prospective cohort study was performed in 7,903 participants. W-3 PUFA intake and fish consumption were ascertained through a validated semi-quantitative food frequency questionnaire. The outcomes after 2 years of follow-up were: (1) Incident mental disorder (depression, anxiety, or stress), (2) incident depression, and (3) incident anxiety. Logistic regression models and generalized additive models were fit to assess the relationship between w-3 PUFA intake or fish consumption and the incidence of these outcomes. Odds ratios (OR) and their 95% confidence intervals (CI) were calculated. RESULTS: 173 cases of depression, 335 cases of anxiety, and 4 cases of stress were observed during 2-year follow-up. ORs (95% CI) of mental disorder for successive quintiles of energy-adjusted w-3 PUFA intake were 1 (reference), 0.72 (0.52-0.99), 0.79 (0.58-1.08), 0.65 (0.47-0.90), and 1.04 (0.78-1.40). Subjects with a moderate consumption of fish (third and fourth quintiles of consumption: median of each quintile 83.3 and 112 g/day, respectively) had a relative risk reduction higher than 30%. CONCLUSIONS: A potential benefit of w-3 PUFA intake on total mental disorders is suggested, although no linear trend was apparent.
BACKGROUND: Very long chain omega-3 fatty acids (w-3 PUFA) intake and fish consumption have been suggested as protective factors against neuropsychiatric disorders but there is scarcity of large cohort studies assessing this association. AIM OF THE STUDY: To assess the association between w-3-PUFA intake and fish consumption and mental disorders. METHODS: A prospective cohort study was performed in 7,903 participants. W-3 PUFA intake and fish consumption were ascertained through a validated semi-quantitative food frequency questionnaire. The outcomes after 2 years of follow-up were: (1) Incident mental disorder (depression, anxiety, or stress), (2) incident depression, and (3) incident anxiety. Logistic regression models and generalized additive models were fit to assess the relationship between w-3 PUFA intake or fish consumption and the incidence of these outcomes. Odds ratios (OR) and their 95% confidence intervals (CI) were calculated. RESULTS: 173 cases of depression, 335 cases of anxiety, and 4 cases of stress were observed during 2-year follow-up. ORs (95% CI) of mental disorder for successive quintiles of energy-adjusted w-3 PUFA intake were 1 (reference), 0.72 (0.52-0.99), 0.79 (0.58-1.08), 0.65 (0.47-0.90), and 1.04 (0.78-1.40). Subjects with a moderate consumption of fish (third and fourth quintiles of consumption: median of each quintile 83.3 and 112 g/day, respectively) had a relative risk reduction higher than 30%. CONCLUSIONS: A potential benefit of w-3 PUFA intake on total mental disorders is suggested, although no linear trend was apparent.
Authors: Reeta Hakkarainen; Timo Partonen; Jari Haukka; Jarmo Virtamo; Demetrius Albanes; Jouko Lönnqvist Journal: Am J Psychiatry Date: 2004-03 Impact factor: 18.112
Authors: S Salvini; D J Hunter; L Sampson; M J Stampfer; G A Colditz; B Rosner; W C Willett Journal: Int J Epidemiol Date: 1989-12 Impact factor: 7.196
Authors: William H Coryell; Douglas R Langbehn; Andrew W Norris; Jian-Rong Yao; Lilian N Dindo; Chadi A Calarge Journal: Psychiatry Res Date: 2017-06-21 Impact factor: 3.222
Authors: Jane E Persons; Jennifer G Robinson; Eric M Ammann; William H Coryell; Mark A Espeland; William S Harris; JoAnn E Manson; Jess G Fiedorowicz Journal: Int J Geriatr Psychiatry Date: 2013-12-11 Impact factor: 3.485
Authors: May A Beydoun; Marie T Fanelli Kuczmarski; Hind A Beydoun; Ola S Rostant; Michele K Evans; Alan B Zonderman Journal: Am J Epidemiol Date: 2015-04-07 Impact factor: 4.897
Authors: Alexander C Tsai; Michel Lucas; Olivia I Okereke; Eilis J O'Reilly; Fariba Mirzaei; Ichiro Kawachi; Alberto Ascherio; Walter C Willett Journal: Am J Epidemiol Date: 2014-05-08 Impact factor: 4.897
Authors: Anna Liisa Suominen-Taipale; Timo Partonen; Anu W Turunen; Satu Männistö; Antti Jula; Pia K Verkasalo Journal: PLoS One Date: 2010-05-07 Impact factor: 3.240
Authors: Tasnime N Akbaraly; Eric J Brunner; Jane E Ferrie; Michael G Marmot; Mika Kivimaki; Archana Singh-Manoux Journal: Br J Psychiatry Date: 2009-11 Impact factor: 9.319