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Literature DB >> 17710620

Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients.

Joseph Meletiadis¹, Thomas J Walsh, Eun Hwa Choi, Peter G Pappas, David Ennis, Jeffrey Douglas, George A Pankey, Robert A Larsen, Richard J Hamill, Stephen Chanock.

Abstract

A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.

Entities: Disease Gene Species

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Substances：

Year: 2007 PMID： 17710620 DOI： 10.1080/13693780701390140

Source DB: PubMed Journal: Med Mycol ISSN： 1369-3786 Impact factor: 4.076

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Cited

24 in total

1. The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity.

Authors: Mitra Shourian; Adam Flaczyk; Isabelle Angers; Barbara C Mindt; Jörg H Fritz; Salman T Qureshi
Journal: Infect Immun Date: 2015-09-14 Impact factor: 3.441

2. Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea.

Authors: Young Hwa Choi; Popchai Ngamskulrungroj; Ashok Varma; Edward Sionov; Soo Myung Hwang; Fabian Carriconde; Wieland Meyer; Anastasia P Litvintseva; Wee Gyo Lee; Jong Hee Shin; Eui-Chong Kim; Kyung Won Lee; Tae Yeal Choi; Yeong Seon Lee; Kyung J Kwon-Chung
Journal: FEMS Yeast Res Date: 2010-05-19 Impact factor: 2.796

Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients.

1. The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity.

2. Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea.

Review 3. Host immunity to Cryptococcus neoformans.

Review 4. Cryptococcal Disease in HIV-Infected Children.

5. Fc receptor-mediated immune responses: new tools but increased complexity in HIV prevention.

Review 6. Cryptococcal therapies and drug targets: the old, the new and the promising.

7. Genetic Susceptibility to Fungal Infections: What is in the Genes?

8. Association of Fcγ receptor IIB polymorphism with cryptococcal meningitis in HIV-uninfected Chinese patients.

Review 9. Pathogen and host genetics underpinning cryptococcal disease.

10. Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China.