OBJECTIVE: Using (1)H-nuclear magnetic resonance spectroscopy and chemometrics, we sought to establish the metabolic profile for preeclampsia and to identify biomarkers that would permit a distinction between women with a normal pregnancy and those suffering from preeclampsia. METHODS: Plasma samples from 11 normotensive pregnant women and 11 women with preeclampsia were analyzed. Principal component analysis was applied to differentiate between the two groups of patients. RESULTS: Lipid concentrations were found to be significantly lower in the plasma of patients suffering from preeclampsia than those in normotensive pregnant women (p = 0.031). There is also evidence to suggest that ketone body constituents may contribute to the discrimination. CONCLUSION: (1)H-nuclear magnetic resonance-based metabolic profiling can detect patients with preeclampsia.
OBJECTIVE: Using (1)H-nuclear magnetic resonance spectroscopy and chemometrics, we sought to establish the metabolic profile for preeclampsia and to identify biomarkers that would permit a distinction between women with a normal pregnancy and those suffering from preeclampsia. METHODS: Plasma samples from 11 normotensive pregnant women and 11 women with preeclampsia were analyzed. Principal component analysis was applied to differentiate between the two groups of patients. RESULTS:Lipid concentrations were found to be significantly lower in the plasma of patients suffering from preeclampsia than those in normotensive pregnant women (p = 0.031). There is also evidence to suggest that ketone body constituents may contribute to the discrimination. CONCLUSION: (1)H-nuclear magnetic resonance-based metabolic profiling can detect patients with preeclampsia.
Authors: Rachel S Kelly; Rachel T Giorgio; Bo L Chawes; Natalia I Palacios; Kathryn J Gray; Hoooman Mirzakhani; Ann Wu; Kevin Blighe; Scott T Weiss; Jessica Lasky-Su Journal: Metabolomics Date: 2017-06-12 Impact factor: 4.290
Authors: Daniel Sachse; Line Sletner; Kjersti Mørkrid; Anne Karen Jenum; Kåre I Birkeland; Frode Rise; Armin P Piehler; Jens Petter Berg Journal: PLoS One Date: 2012-12-21 Impact factor: 3.240
Authors: Lina Youssef; Francesca Crovetto; Rui Vasco Simoes; Jezid Miranda; Cristina Paules; Miquel Blasco; Marta Palomo; Héctor García-Calderó; Olga Tura-Ceide; Ana Paula Dantas; Virginia Hernandez-Gea; Pol Herrero; Núria Canela; Josep Maria Campistol; Joan Carles Garcia-Pagan; Maribel Diaz-Ricart; Eduard Gratacos; Fatima Crispi Journal: Life (Basel) Date: 2022-01-07