OBJECTIVE: To test the potential adjuvant effect of repetitive transcranial magnetic stimulation (rTMS) on motor learning in a group of stroke survivors undergoing constraint-induced therapy (CIT) for upper-limb hemiparesis. DESIGN: This was a prospective randomized, double-blind, sham-controlled, parallel group study. Nineteen individuals, one or more years poststroke, were randomized to either a rTMS + CIT (n = 9) or a sham rTMS + CIT (n = 10) group and participated in the 2-wk intervention. RESULTS: Regardless of group assignment, participants demonstrated significant gains on the primary outcome measures: the Wolf Motor Function Test (WMFT) and the Motor Activity Log (MAL)--Amount of Use, and on secondary outcome measures including the Box and Block Test (BBT) and the MAL--How Well. Participants receiving rTMS failed to show differential improvement on either primary outcome measure. CONCLUSIONS: Although this study provided further evidence that even relatively brief sessions of CIT can have a substantial effect, it provided no support for adjuvant use of rTMS.
RCT Entities:
OBJECTIVE: To test the potential adjuvant effect of repetitive transcranial magnetic stimulation (rTMS) on motor learning in a group of stroke survivors undergoing constraint-induced therapy (CIT) for upper-limb hemiparesis. DESIGN: This was a prospective randomized, double-blind, sham-controlled, parallel group study. Nineteen individuals, one or more years poststroke, were randomized to either a rTMS + CIT (n = 9) or a sham rTMS + CIT (n = 10) group and participated in the 2-wk intervention. RESULTS: Regardless of group assignment, participants demonstrated significant gains on the primary outcome measures: the Wolf Motor Function Test (WMFT) and the Motor Activity Log (MAL)--Amount of Use, and on secondary outcome measures including the Box and Block Test (BBT) and the MAL--How Well. Participants receiving rTMS failed to show differential improvement on either primary outcome measure. CONCLUSIONS: Although this study provided further evidence that even relatively brief sessions of CIT can have a substantial effect, it provided no support for adjuvant use of rTMS.
Authors: Steven L Wolf; Paul A Thompson; David M Morris; Dorian K Rose; Carolee J Winstein; Edward Taub; Carol Giuliani; Sonya L Pearson Journal: Neurorehabil Neural Repair Date: 2005-09 Impact factor: 3.919
Authors: Lucy Lee; Hartwig R Siebner; James B Rowe; Vincenzo Rizzo; John C Rothwell; Richard S J Frackowiak; Karl J Friston Journal: J Neurosci Date: 2003-06-15 Impact factor: 6.167
Authors: Vishwanath Sankarasubramanian; Andre G Machado; Adriana B Conforto; Kelsey A Potter-Baker; David A Cunningham; Nicole M Varnerin; Xiaofeng Wang; Ken Sakaie; Ela B Plow Journal: Clin Neurophysiol Date: 2017-03-21 Impact factor: 3.708