Literature DB >> 17695375

Flatiron mice and ferroportin disease.

Erin E Johnson1, Marianne Wessling-Resnick.   

Abstract

Flatiron mice provide the first genetic model that fully recapitulates the iron-loading disorder ferroportin disease. Unlike the other known genetic causes of hemochromatosis, missense mutations in the ferroportin gene are autosomal dominant. These new findings show that ferroportin disease results from dominant negative effects rather than haplo-insufficiency.

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Year:  2007        PMID： 17695375      PMCID： PMC2494882          DOI： 10.1111/j.1753-4887.2007.tb00312.x

Source DB:  PubMed          Journal:  Nutr Rev        ISSN： 0029-6643            Impact factor:   7.110


  15 in total

Review 1.  Iron overload due to mutations in ferroportin.

Authors:  Ivana De Domenico; Diane McVey Ward; Giovanni Musci; Jerry Kaplan
Journal:  Haematologica       Date:  2006-01       Impact factor: 9.941

Review 2.  Molecular insights into the pathogenesis of hereditary haemochromatosis.

Authors:  A Pietrangelo
Journal:  Gut       Date:  2006-04       Impact factor: 23.059

3.  A novel mammalian iron-regulated protein involved in intracellular iron metabolism.

Authors:  S Abboud; D J Haile
Journal:  J Biol Chem       Date:  2000-06-30       Impact factor: 5.157

4.  Ferroportin1 is required for normal iron cycling in zebrafish.

Authors:  Paula G Fraenkel; David Traver; Adriana Donovan; David Zahrieh; Leonard I Zon
Journal:  J Clin Invest       Date:  2005-05-05       Impact factor: 14.808

5.  The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.

Authors:  Adriana Donovan; Christine A Lima; Jack L Pinkus; Geraldine S Pinkus; Leonard I Zon; Sylvie Robine; Nancy C Andrews
Journal:  Cell Metab       Date:  2005-03       Impact factor: 27.287

Review 6.  Iron imports. IV. Hepcidin and regulation of body iron metabolism.

Authors:  Tomas Ganz; Elizabeta Nemeth
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2006-02       Impact factor: 4.052

7.  Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.

Authors:  A Donovan; A Brownlie; Y Zhou; J Shepard; S J Pratt; J Moynihan; B H Paw; A Drejer; B Barut; A Zapata; T C Law; C Brugnara; S E Lux; G S Pinkus; J L Pinkus; P D Kingsley; J Palis; M D Fleming; N C Andrews; L I Zon
Journal:  Nature       Date:  2000-02-17       Impact factor: 49.962

8.  Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.

Authors:  Elizabeta Nemeth; Marie S Tuttle; Julie Powelson; Michael B Vaughn; Adriana Donovan; Diane McVey Ward; Tomas Ganz; Jerry Kaplan
Journal:  Science       Date:  2004-10-28       Impact factor: 47.728

Review 9.  The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1).

Authors:  Andrew T McKie; David J Barlow
Journal:  Pflugers Arch       Date:  2003-06-27       Impact factor: 3.657

10.  The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease.

Authors:  Irene E Zohn; Ivana De Domenico; Andrew Pollock; Diane McVey Ward; Jessica F Goodman; Xiayun Liang; Amaru J Sanchez; Lee Niswander; Jerry Kaplan
Journal:  Blood       Date:  2007-02-08       Impact factor: 22.113
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  4 in total

Review 1.  Hereditary hemochromatosis and transferrin receptor 2.

Authors:  Juxing Chen; Caroline A Enns
Journal:  Biochim Biophys Acta       Date:  2011-08-16

Review 2.  Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity.

Authors:  Lijian Wang; Bobby J Cherayil
Journal:  J Innate Immun       Date:  2009-03-23       Impact factor: 7.349

3.  A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages.

Authors:  Stella Ekaputri; Eun-Kyung Choi; Manuela Sabelli; Luisa Aring; Kelsie J Green; JuOae Chang; Kai Bao; Hak Soo Choi; Shigeki Iwase; Jonghan Kim; Elena Corradini; Antonello Pietrangelo; Martin D Burke; Young Ah Seo
Journal:  Proc Natl Acad Sci U S A       Date:  2022-06-22       Impact factor: 12.779

Review 4.  Nramp1 and Other Transporters Involved in Metal Withholding during Infection.

Authors:  Marianne Wessling-Resnick
Journal:  J Biol Chem       Date:  2015-06-08       Impact factor: 5.157
  4 in total

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