Literature DB >> 12836025

The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1).

Andrew T McKie1, David J Barlow.   

Abstract

The iron regulated-transporter-1 (Ireg1, also known as ferroportin or metal transporter protein-1, MTP1) appears to be the sole member of the SLC40 transporter family. It functions as a universal efflux pathway for iron in a number of cell types. The protein is most highly expressed in mature enterocytes of the duodenum, in syncytiotrophoblasts, which separate foetal and maternal circulations in the placenta, and in macrophages responsible for recycling iron from breakdown of aged red blood cells.

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Year:  2003        PMID： 12836025     DOI： 10.1007/s00424-003-1102-3

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  37 in total

1.  A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4.

Authors:  Antonella Roetto; Alison T Merryweather-Clarke; Filomena Daraio; Karen Livesey; Jennifer J Pointon; Giuliana Barbabietola; Antonio Piga; Peter H Mackie; Kathryn J H Robson; Clara Camaschella
Journal:  Blood       Date:  2002-07-15       Impact factor: 22.113

2.  A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis.

Authors:  O T Njajou; N Vaessen; M Joosse; B Berghuis; J W van Dongen; M H Breuning; P J Snijders; W P Rutten; L A Sandkuijl; B A Oostra; C M van Duijn; P Heutink
Journal:  Nat Genet       Date:  2001-07       Impact factor: 38.330

3.  A novel mammalian iron-regulated protein involved in intracellular iron metabolism.

Authors:  S Abboud; D J Haile
Journal:  J Biol Chem       Date:  2000-06-30       Impact factor: 5.157

4.  The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation.

Authors:  Gaël Nicolas; Caroline Chauvet; Lydie Viatte; Jean Louis Danan; Xavier Bigard; Isabelle Devaux; Carole Beaumont; Axel Kahn; Sophie Vaulont
Journal:  J Clin Invest       Date:  2002-10       Impact factor: 14.808

5.  An iron delivery pathway mediated by a lipocalin.

Authors:  Jun Yang; David Goetz; Jau Yi Li; Wenge Wang; Kiyoshi Mori; Daria Setlik; Tonggong Du; Hediye Erdjument-Bromage; Paul Tempst; Roland Strong; Jonathan Barasch
Journal:  Mol Cell       Date:  2002-11       Impact factor: 17.970

Review 6.  Genetics of haemochromatosis.

Authors:  Adrian Bomford
Journal:  Lancet       Date:  2002-11-23       Impact factor: 79.321

7.  Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.

Authors:  M D Fleming; C C Trenor; M A Su; D Foernzler; D R Beier; W F Dietrich; N C Andrews
Journal:  Nat Genet       Date:  1997-08       Impact factor: 38.330

8.  Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.

Authors:  C D Vulpe; Y M Kuo; T L Murphy; L Cowley; C Askwith; N Libina; J Gitschier; G J Anderson
Journal:  Nat Genet       Date:  1999-02       Impact factor: 38.330

9.  The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

Authors:  C Camaschella; A Roetto; A Calì; M De Gobbi; G Garozzo; M Carella; N Majorano; A Totaro; P Gasparini
Journal:  Nat Genet       Date:  2000-05       Impact factor: 38.330

10.  Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis.

Authors:  Antonella Roetto; George Papanikolaou; Marianna Politou; Federica Alberti; Domenico Girelli; John Christakis; Dimitris Loukopoulos; Clara Camaschella
Journal:  Nat Genet       Date:  2002-12-09       Impact factor: 38.330
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  24 in total

Review 1.  Flatiron mice and ferroportin disease.

Authors:  Erin E Johnson; Marianne Wessling-Resnick
Journal:  Nutr Rev       Date:  2007-07       Impact factor: 7.110

2.  Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess.

Authors:  Kamila Balusikova; Jitka Neubauerova; Marketa Dostalikova-Cimburova; Jiri Horak; Jan Kovar
Journal:  Mol Cell Biochem       Date:  2008-10-02       Impact factor: 3.396

3.  The Concise Guide to PHARMACOLOGY 2013/14: transporters.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

4.  Ferroportin and iron regulation in breast cancer progression and prognosis.

Authors:  Zandra K Pinnix; Lance D Miller; Wei Wang; Ralph D'Agostino; Tim Kute; Mark C Willingham; Heather Hatcher; Lia Tesfay; Guangchao Sui; Xiumin Di; Suzy V Torti; Frank M Torti
Journal:  Sci Transl Med       Date:  2010-08-04       Impact factor: 17.956

Review 5.  Pharmacology of iron transport.

Authors:  Shaina L Byrne; Divya Krishnamurthy; Marianne Wessling-Resnick
Journal:  Annu Rev Pharmacol Toxicol       Date:  2012-09-27       Impact factor: 13.820

6.  Normal iron metabolism and the pathophysiology of iron overload disorders.

Authors:  Chiang W Siah; John Ombiga; Leon A Adams; Debbie Trinder; John K Olynyk
Journal:  Clin Biochem Rev       Date:  2006-02

7.  Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin.

Authors:  Mitchell D Knutson; Mohamed Oukka; Lindsey M Koss; Fikret Aydemir; Marianne Wessling-Resnick
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-21       Impact factor: 11.205

8.  Ferroportin and erythroid cells: an update.

Authors:  Luciano Cianetti; Marco Gabbianelli; Nadia Maria Sposi
Journal:  Adv Hematol       Date:  2010-08-11

9.  Analysis and update of the human solute carrier (SLC) gene superfamily.

Authors:  Lei He; Konstandinos Vasiliou; Daniel W Nebert
Journal:  Hum Genomics       Date:  2009-01       Impact factor: 4.639

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
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