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Literature DB >> 20375603

Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity.

Abstract

Iron is an essential micronutrient for both microbial pathogens and their mammalian hosts. Changes in iron availability and distribution have significant effects on pathogen virulence and on the immune response to infection. Recent advances in our understanding of the molecular regulation of iron metabolism have shed new light on how alterations in iron homeostasis both contribute to and influence innate immunity. In this article, we review what is currently known about the role of iron in the response to infection. Copyright 2009 S. Karger AG, Basel.

Entities: Chemical Disease Species

Mesh：

Substances：
Iron

Year: 2009 PMID： 20375603 PMCID： PMC3969595 DOI： 10.1159/000210016

Source DB: PubMed Journal: J Innate Immun ISSN： 1662-811X Impact factor: 7.349

88 in total

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