Literature DB >> 17693957

Synthesis and antimicrobial activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds having a D,L-methionine moiety.

Otilia Pintilie1, Lenuta Profire, Valeriu Sunel, Marcel Popa, Aurel Pui.   

Abstract

New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.

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Year:  2007        PMID： 17693957      PMCID： PMC6149405          DOI： 10.3390/12010103

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  16 in total

1.  Synthesis of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives and evaluation of their antidepressant and anxiolytic activity.

Authors:  F Clerici; D Pocar; M Guido; A Loche; V Perlini; M Brufani
Journal:  J Med Chem       Date:  2001-03-15       Impact factor: 7.446

2.  Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.

Authors:  Monika Wujec; Monika Pitucha; Maria Dobosz; Urszula Kosikowska; Anna Malm
Journal:  Acta Pharm       Date:  2004-09       Impact factor: 2.230

3.  Synthesis and antinociceptive activity of [(2-oxobenzothiazolin-3-yl)methyl]-4-alkyl/aryl-1,2,4-triazoline-5-thiones.

Authors:  M Gökce; B Cakir; K Erol; M F Sahin
Journal:  Arch Pharm (Weinheim)       Date:  2001-09       Impact factor: 3.751

4.  3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as anti-inflammatory and analgesic agents.

Authors:  S Schenone; O Bruno; A Ranise; F Bondavalli; W Filippelli; G Falcone; L Giordano; M R Vitelli
Journal:  Bioorg Med Chem       Date:  2001-08       Impact factor: 3.641

5.  Synthesis and fungicidal activity against Rhizoctonia solani of 2-alkyl (Alkylthio)-5-pyrazolyl-1,3,4-oxadiazoles (Thiadiazoles).

Authors:  H Chen; Z Li; Y Han
Journal:  J Agric Food Chem       Date:  2000-11       Impact factor: 5.279

6.  Synthesis, fungicidal activity, and QSAR of pyridazinonethiadiazoles.

Authors:  Xia Juan Zou; Gui Yu Jin; Zu Xing Zhang
Journal:  J Agric Food Chem       Date:  2002-03-13       Impact factor: 5.279

7.  Synthesis and antimycobacterial activity of [5-(pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid arylidene-hydrazide derivatives.

Authors:  M G Mamolo; V Falagiani; D Zampieri; L Vio; E Banfi
Journal:  Farmaco       Date:  2001-08

8.  Subunit interaction in unadenylylated glutamine synthetase from Escherichia coli. Evidence from methionine sulfoximine inhibition studies.

Authors:  S G Rhee; P B Chock; F C Wedler; Y Sugiyama
Journal:  J Biol Chem       Date:  1981-01-25       Impact factor: 5.157

9.  Heterocyclic analogues of the antihypertensive beta-adrenergic blocking agent (S)-2-[3-(ter-butylamino)-2-hydroxypropoxy]-3-cyanopyridine.

Authors:  J J Baldwin; E L Engelhardt; R Hirschmann; G S Ponticello; J G Atkinson; B K Wasson; C S Sweet; A Scriabine
Journal:  J Med Chem       Date:  1980-01       Impact factor: 7.446

10.  Synthesis, lipophilicity and biological evaluation of indole-containing derivatives of 1,3,4-thiadiazole and 1,2, 4-triazole.

Authors:  A Varvaresou; T Siatra-Papastaikoudi; A Dalla Tsotinis; A Tsantili-Kakoulidou; A Vamvakides
Journal:  Farmaco       Date:  1998-05-30
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  9 in total

1.  Studies on Absorption and Emission Characteristics of Inclusion Complexes of Some 4-Arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols.

Authors:  Sunakar Panda; Sashikanta Nayak
Journal:  J Fluoresc       Date:  2015-11-21       Impact factor: 2.217

2.  Discovery of potential anti-infectives against Staphylococcus aureus using a Caenorhabditis elegans infection model.

Authors:  Cin Kong; Wageeh A Yehye; Noorsaadah Abd Rahman; Man-Wah Tan; Sheila Nathan
Journal:  BMC Complement Altern Med       Date:  2014-01-06       Impact factor: 3.659

Review 3.  2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents.

Authors:  Georgeta Serban; Oana Stanasel; Sanda Bota; Eugenia Serban
Journal:  Drug Des Devel Ther       Date:  2018-05-31       Impact factor: 4.162

4.  Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates.

Authors:  Reem I Al-Wabli; Mona A Alsulami; Sarah I Bukhari; Nadine M S Moubayed; Maha S Al-Mutairi; Mohamed I Attia
Journal:  Molecules       Date:  2021-04-15       Impact factor: 4.411

5.  Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity.

Authors:  Corina Popovici; Cristina-Maria Pavel; Valeriu Sunel; Corina Cheptea; Dan Gheorghe Dimitriu; Dana Ortansa Dorohoi; Diana David; Valentina Closca; Marcel Popa
Journal:  Int J Mol Sci       Date:  2021-11-09       Impact factor: 5.923

6.  New di-(beta-chloroethyl)-alpha-amides on N-(meta-acylamino-benzoyl)- D,L-aminoacid supports with antitumoral activity.

Authors:  Valeriu Sunel; Marcel Popa; Jacques Desbrières; Lenuta Profire; Pintilie Otilia; Lionte Catalina
Journal:  Molecules       Date:  2008-01-28       Impact factor: 4.411

7.  Effects of a thiosemicarbazide camphene derivative on Trichophyton mentagrophytes.

Authors:  Mirian Ueda Yamaguchi; Ana Paula Barbosa da Silva; Tânia Ueda-Nakamura; Benedito Prado Dias Filho; Cleuza Conceição da Silva; Celso Vataru Nakamura
Journal:  Molecules       Date:  2009-05-13       Impact factor: 4.411

8.  Synthesis and biological activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds containing a phenylalanine moiety.

Authors:  Mihaela Moise; Valeriu Sunel; Lenuta Profire; Marcel Popa; Jacques Desbrieres; Cristian Peptu
Journal:  Molecules       Date:  2009-07-16       Impact factor: 4.411

9.  Solvent-Free Synthesis, In Vitro and In Silico Studies of Novel Potential 1,3,4-Thiadiazole-Based Molecules against Microbial Pathogens.

Authors:  Ihsan A Shehadi; Mohamad T Abdelrahman; Mohamed Abdelraof; Huda R M Rashdan
Journal:  Molecules       Date:  2022-01-06       Impact factor: 4.411
  9 in total

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