Literature DB >> 11504651

3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as anti-inflammatory and analgesic agents.

S Schenone1, O Bruno, A Ranise, F Bondavalli, W Filippelli, G Falcone, L Giordano, M R Vitelli.   

Abstract

Two series of 3-arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones 2 with potential anti-inflammatory and analgesic activity were prepared and tested. Pharmacological results revealed that all the title compounds, endowed with an arylsulphonyl side chain, possess good antalgic activity and fair anti-inflammatory properties. The analgesic profile of the two series, evaluated by the acetic acid writhing test, showed that compounds 2c, 2f and 2h, in particular, were the most active. Structure-activity relationships are briefly discussed.

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Year:  2001        PMID： 11504651     DOI： 10.1016/s0968-0896(01)00121-3

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

1.  Synthesis and antimicrobial activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds having a D,L-methionine moiety.

Authors:  Otilia Pintilie; Lenuta Profire; Valeriu Sunel; Marcel Popa; Aurel Pui
Journal:  Molecules       Date:  2007-01-29       Impact factor: 4.411

2.  Synthesis and antimicrobial studies of some novel bis-[1,3,4]thiadiazole and bis-thiazole pendant to thieno[2,3-b]thiophene moiety.

Authors:  Nabila Abdelshafy Kheder; Yahia Nasser Mabkhot
Journal:  Int J Mol Sci       Date:  2012-03-19       Impact factor: 6.208

3.  Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates.

Authors:  Reem I Al-Wabli; Mona A Alsulami; Sarah I Bukhari; Nadine M S Moubayed; Maha S Al-Mutairi; Mohamed I Attia
Journal:  Molecules       Date:  2021-04-15       Impact factor: 4.411

4.  I2/DMSO-catalyzed one-pot approach for the synthesis of 1,3,4-selenadiazoles.

Authors:  Suresh Kuarm Bowroju; Rajitha Bavanthula
Journal:  RSC Adv       Date:  2021-02-02       Impact factor: 3.361

5.  Synthesis and biological activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds containing a phenylalanine moiety.

Authors:  Mihaela Moise; Valeriu Sunel; Lenuta Profire; Marcel Popa; Jacques Desbrieres; Cristian Peptu
Journal:  Molecules       Date:  2009-07-16       Impact factor: 4.411
  5 in total

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