Literature DB >> 1768841

Hexadecylphosphocholine: determination of serum concentrations in rats.

C Unger1, E Fleer, W Damenz, P Hilgard, G Nagel, H Eibl.   

Abstract

A sensitive and quantitative determination of the concentration of hexadecylphosphocholine in serum is described. After HPLC separation, the concentration of hexadecylphosphocholine is determined by phosphate analysis. According to this method, the half-life of hexadecylphosphocholine in serum rats is about 96 h. A steady-state serum concentration of 110 microM is reached after 2 weeks of daily treatment with 10 mg/kg hexadecylphosphocholine. The described method has general application for other compounds with similar structures. For instance, serum levels of alkyllysophosphocholines such as 1-0-octadecyl-2-0-methyl- racglycero-3-phosphocholine can be determined using this method.

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Year:  1991        PMID： 1768841

Source DB:  PubMed          Journal:  J Lipid Mediat        ISSN： 0921-8319


  8 in total

1.  Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.

Authors:  Fred Widmer; Lesley C Wright; Daniel Obando; Rosemary Handke; Ranjini Ganendren; David H Ellis; Tania C Sorrell
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

2.  Effects of miltefosine and other alkylphosphocholines on human intestinal parasite Entamoeba histolytica.

Authors:  K Seifert; M Duchêne; W H Wernsdorfer; H Kollaritsch; O Scheiner; G Wiedermann; T Hottkowitz; H Eibl
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

3.  In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes.

Authors:  Zhongsheng Tong; Fred Widmer; Tania C Sorrell; Zofia Guse; Katrina A Jolliffe; Catriona Halliday; Ok Cha Lee; Fanrong Kong; Lesley C Wright; Sharon C A Chen
Journal:  Antimicrob Agents Chemother       Date:  2007-03-19       Impact factor: 5.191

Review 4.  Alkylphosphocholines: a new class of membrane-active anticancer agents.

Authors:  P Hilgard; T Klenner; J Stekar; C Unger
Journal:  Cancer Chemother Pharmacol       Date:  1993       Impact factor: 3.333

5.  Alkylphosphocholines: influence of structural variation on biodistribution at antineoplastically active concentrations.

Authors:  J Kötting; M R Berger; C Unger; H Eibl
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

6.  Hexadecylphosphocholine: oral treatment of visceral leishmaniasis in mice.

Authors:  A Kuhlencord; T Maniera; H Eibl; C Unger
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

7.  Distribution of hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine in rat tissues during steady-state treatment.

Authors:  N Marschner; J Kötting; H Eibl; C Unger
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

8.  Pharmacokinetic behavior and antineoplastic activity of liposomal hexadecylphosphocholine.

Authors:  P Kaufmann-Kolle; J Drevs; M R Berger; J Kötting; N Marschner; C Unger; H Eibl
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333
  8 in total

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