Literature DB >> 1768573

The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions.

B Herd1, H Wynne, P Wright, O James, K Woodhouse.   

Abstract

Glucuronidation and sulphation were studied in vitro in human liver samples from 22 subjects aged 40-89 years using paracetamol as substrate. There was no significant correlation with age for the activity of either enzyme pathway. These results provide further evidence that age per se does not have a major effect on the activities of hepatic metabolising enzymes.

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Year:  1991        PMID： 1768573      PMCID： PMC1368562     

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  17 in total

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Authors:  D Howie; P I Adriaenssens; L F Prescott
Journal:  J Pharm Pharmacol       Date:  1977-04       Impact factor: 3.765

2.  VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.

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Journal:  Biochem Pharmacol       Date:  1964-07       Impact factor: 5.858

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Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

Review 4.  Aging and drug disposition: an update.

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Journal:  Pharmacol Rev       Date:  1985-06       Impact factor: 25.468

5.  Drug metabolism in human liver in vitro: establishment of a human liver bank.

Authors:  C von Bahr; C G Groth; H Jansson; G Lundgren; M Lind; H Glaumann
Journal:  Clin Pharmacol Ther       Date:  1980-06       Impact factor: 6.875

6.  Adverse reactions to prescribed drugs in the elderly: a multicentre investigation.

Authors:  J Williamson; J M Chopin
Journal:  Age Ageing       Date:  1980-05       Impact factor: 10.668

7.  Effects of age and gender on in vitro properties of human liver microsomal monooxygenases.

Authors:  D L Schmucker; K W Woodhouse; R K Wang; H Wynne; O F James; M McManus; P Kremers
Journal:  Clin Pharmacol Ther       Date:  1990-10       Impact factor: 6.875

8.  Influence of age-related changes in rodent liver morphology and physiology on drug metabolism--a review.

Authors:  C F van Bezooijen
Journal:  Mech Ageing Dev       Date:  1984 Apr-May       Impact factor: 5.432

9.  Influence of sex and oral contraceptive steroids on paracetamol metabolism.

Authors:  J O Miners; J Attwood; D J Birkett
Journal:  Br J Clin Pharmacol       Date:  1983-11       Impact factor: 4.335

Review 10.  Kinetics and metabolism of paracetamol and phenacetin.

Authors:  L F Prescott
Journal:  Br J Clin Pharmacol       Date:  1980-10       Impact factor: 4.335
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  16 in total

Review 1.  Predicting and preventing adverse drug reactions in the very old.

Authors:  Louis Merle; Marie-Laure Laroche; Thierry Dantoine; Jean-Pierre Charmes
Journal:  Drugs Aging       Date:  2005       Impact factor: 3.923

Review 2.  Assessment of liver metabolic function. Clinical implications.

Authors:  J Brockmöller; I Roots
Journal:  Clin Pharmacokinet       Date:  1994-09       Impact factor: 6.447

3.  The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis.

Authors:  D G Le Couteur; A J McLean
Journal:  Clin Pharmacokinet       Date:  1998-05       Impact factor: 6.447

4.  Repository Describing an Aging Population to Inform Physiologically Based Pharmacokinetic Models Considering Anatomical, Physiological, and Biological Age-Dependent Changes.

Authors:  Felix Stader; Marco Siccardi; Manuel Battegay; Hannah Kinvig; Melissa A Penny; Catia Marzolini
Journal:  Clin Pharmacokinet       Date:  2019-04       Impact factor: 6.447

Review 5.  Incorporating pharmacokinetic data into personalised prescribing for older people: challenges and opportunities.

Authors:  Arduino A Mangoni; Elzbieta A Jarmuzewska
Journal:  Eur Geriatr Med       Date:  2021-01-08       Impact factor: 1.710

Review 6.  Age-related changes in the gastrointestinal system. Effects on drug therapy.

Authors:  F L Iber; P A Murphy; E S Connor
Journal:  Drugs Aging       Date:  1994-07       Impact factor: 3.923

Review 7.  Pharmacokinetics of drugs in the elderly.

Authors:  K W Woodhouse
Journal:  J R Soc Med       Date:  1994       Impact factor: 5.344

8.  Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.

Authors:  Ann M Moyer; Brooke L Fridley; Gregory D Jenkins; Anthony J Batzler; Linda L Pelleymounter; Krishna R Kalari; Yuan Ji; Yubo Chai; Kendra K S Nordgren; Richard M Weinshilboum
Journal:  Toxicol Sci       Date:  2010-12-22       Impact factor: 4.849

9.  The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.

Authors:  John Mach; Aniko Huizer-Pajkos; Victoria C Cogger; Catriona McKenzie; David G Le Couteur; Brett E Jones; Rafael de Cabo; Sarah N Hilmer
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-07-17       Impact factor: 6.053

10.  The influence of age, liver size and enantiomer concentrations on warfarin requirements.

Authors:  H Wynne; L Cope; P Kelly; T Whittingham; C Edwards; F Kamali
Journal:  Br J Clin Pharmacol       Date:  1995-09       Impact factor: 4.335
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