OBJECTIVES: An increased incidence in white matter abnormalities is among the most frequently reported brain change in patients with bipolar disorder. The objective of the present study was to examine white matter tract integrity, using diffusion tensor imaging (DTI), in bipolar patients and healthy comparison subjects. METHODS: Eleven DSM-IV bipolar I patients and 10 healthy age- and sex-matched controls were studied. DTI data were acquired on a 1.5 Tesla scanner. Fractional anisotropy (FA) and diffusivity (trace) were determined from axial images using region of interest (ROI) analyses. The ROIs were manually placed in the midline and forward projecting arms of the genu (anterior) and the midline of the splenium (posterior) of the corpus callosum. RESULTS: Bipolar patients had significantly higher FA in the midline of the genu compared with healthy controls. Regional white matter differences were also observed, with significantly lower FA in the genu than forward projecting regions in both groups and lower FA in the genu than the splenium in controls. CONCLUSIONS: Diffusion tensor imaging revealed significant microstructural differences in the genu, as measured by elevated FA in bipolar patients compared with healthy controls. These preliminary findings further support the hypothesis that anomalous frontal brain mechanisms may be associated with bipolar disorder.
OBJECTIVES: An increased incidence in white matter abnormalities is among the most frequently reported brain change in patients with bipolar disorder. The objective of the present study was to examine white matter tract integrity, using diffusion tensor imaging (DTI), in bipolarpatients and healthy comparison subjects. METHODS: Eleven DSM-IV bipolar Ipatients and 10 healthy age- and sex-matched controls were studied. DTI data were acquired on a 1.5 Tesla scanner. Fractional anisotropy (FA) and diffusivity (trace) were determined from axial images using region of interest (ROI) analyses. The ROIs were manually placed in the midline and forward projecting arms of the genu (anterior) and the midline of the splenium (posterior) of the corpus callosum. RESULTS:Bipolarpatients had significantly higher FA in the midline of the genu compared with healthy controls. Regional white matter differences were also observed, with significantly lower FA in the genu than forward projecting regions in both groups and lower FA in the genu than the splenium in controls. CONCLUSIONS: Diffusion tensor imaging revealed significant microstructural differences in the genu, as measured by elevated FA in bipolarpatients compared with healthy controls. These preliminary findings further support the hypothesis that anomalous frontal brain mechanisms may be associated with bipolar disorder.
Authors: Amelia Versace; Cecile D Ladouceur; Soledad Romero; Boris Birmaher; David A Axelson; David J Kupfer; Mary L Phillips Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-10-29 Impact factor: 8.829
Authors: Tiffany M Chaim; Tianhao Zhang; Marcus V Zanetti; Maria Aparecida da Silva; Mário R Louzã; Jimit Doshi; Mauricio H Serpa; Fabio L S Duran; Sheila C Caetano; Christos Davatzikos; Geraldo F Busatto Journal: PLoS One Date: 2014-10-13 Impact factor: 3.240
Authors: Wang Zhan; Yu Zhang; Susanne G Mueller; Peter Lorenzen; Stathis Hadjidemetriou; Norbert Schuff; Michael W Weiner Journal: Neuroimage Date: 2009-02-20 Impact factor: 6.556
Authors: Alan N Francis; Suraj S Mothi; Ian T Mathew; Neeraj Tandon; Brett Clementz; Godfrey D Pearlson; John A Sweeney; Carol A Tamminga; Matcheri S Keshavan Journal: Biol Psychiatry Date: 2016-01-12 Impact factor: 13.382
Authors: Koji Matsuo; Niels Nielsen; Mark A Nicoletti; John P Hatch; E Serap Monkul; Yoshifumi Watanabe; Giovana B Zunta-Soares; Fabiano G Nery; Jair C Soares Journal: Neurosci Lett Date: 2009-11-20 Impact factor: 3.046
Authors: Taís M Minatogawa-Chang; Maristela S Schaufelberger; Adriana M Ayres; Fábio L S Duran; Elisa K Gutt; Robin M Murray; Teresa M Rushe; Philip K McGuire; Paulo R Menezes; Marcia Scazufca; Geraldo F Busatto Journal: Schizophr Res Date: 2009-07-17 Impact factor: 4.939