Literature DB >> 17661303

Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring.

Woncheol Kim1, Jong Suk Lee, Dongho Lee, Xing Fu Cai, Jin Chul Shin, Kyeong Lee, Choong-Hwan Lee, Sangryeol Ryu, Sang-Gi Paik, Jung Joon Lee, Young-Soo Hong.   

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Year:  2007        PMID： 17661303     DOI： 10.1002/cbic.200700196

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  7 in total

1.  Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library.

Authors:  Jae Kyoung Lee; Jae-Hyuk Jang; Dong-Jin Park; Chang-Jin Kim; Jong Seog Ahn; Bang Yeon Hwang; Young-Soo Hong
Journal:  J Antibiot (Tokyo)       Date:  2016-12-21       Impact factor: 2.649

Review 2.  Metabolic engineering for the production of natural products.

Authors:  Lauren B Pickens; Yi Tang; Yit-Heng Chooi
Journal:  Annu Rev Chem Biomol Eng       Date:  2011       Impact factor: 11.059

3.  Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.

Authors:  Simone Eichner; Timo Eichner; Heinz G Floss; Jörg Fohrer; Edgar Hofer; Florenz Sasse; Carsten Zeilinger; Andreas Kirschning
Journal:  J Am Chem Soc       Date:  2012-01-10       Impact factor: 15.419

Review 4.  Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?

Authors:  Anuj Khandelwal; Vincent M Crowley; Brian S J Blagg
Journal:  Med Res Rev       Date:  2015-05-25       Impact factor: 12.944

5.  Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.

Authors:  Martina Werneburg; Benjamin Busch; Jing He; Martin E A Richter; Longkuan Xiang; Bradley S Moore; Martin Roth; Hans-Martin Dahse; Christian Hertweck
Journal:  J Am Chem Soc       Date:  2010-08-04       Impact factor: 15.419

6.  Enzymatic glycosylation of nonbenzoquinone geldanamycin analogs via Bacillus UDP-glycosyltransferase.

Authors:  Cheng-Zhu Wu; Jae-Hyuk Jang; Mihee Woo; Jong Seog Ahn; Joong Su Kim; Young-Soo Hong
Journal:  Appl Environ Microbiol       Date:  2012-08-24       Impact factor: 4.792

7.  Anti-tumor activity of WK88-1, a novel geldanamycin derivative, in gefitinib-resistant non-small cell lung cancers with Met amplification.

Authors:  Won-Jun Jang; Sung-Keun Jung; Jong-Soon Kang; Joo-Won Jeong; Moon-Kyoung Bae; Sang Hoon Joo; Gyu Hwan Park; Joydeb K Kundu; Young-Soo Hong; Chul-Ho Jeong
Journal:  Cancer Sci       Date:  2014-09-25       Impact factor: 6.716
  7 in total

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