Milind Misra1, Catherine H Schein. 1. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-0857, USA. chschein@utmb.edu
Abstract
MOTIVATION: Properly annotated sequence data for flaviviruses, which cause diseases, such as tick-borne encephalitis (TBE), dengue fever (DF), West Nile (WN) and yellow fever (YF), can aid in the design of antiviral drugs and vaccines to prevent their spread. Flavitrack was designed to help identify conserved sequence motifs, interpret mutational and structural data and track evolution of phenotypic properties. SUMMARY: Flavitrack contains over 590 complete flavivirus genome/protein sequences and information on known mutations and literature references. Each sequence has been manually annotated according to its date and place of isolation, phenotype and lethality. Internal tools are provided to rapidly determine relationships between viruses in Flavitrack and sequences provided by the user.
MOTIVATION: Properly annotated sequence data for flaviviruses, which cause diseases, such as tick-borne encephalitis (TBE), dengue fever (DF), West Nile (WN) and yellow fever (YF), can aid in the design of antiviral drugs and vaccines to prevent their spread. Flavitrack was designed to help identify conserved sequence motifs, interpret mutational and structural data and track evolution of phenotypic properties. SUMMARY: Flavitrack contains over 590 complete flavivirus genome/protein sequences and information on known mutations and literature references. Each sequence has been manually annotated according to its date and place of isolation, phenotype and lethality. Internal tools are provided to rapidly determine relationships between viruses in Flavitrack and sequences provided by the user.
Authors: Surendra S Negi; Andrey A Kolokoltsov; Catherine H Schein; Robert A Davey; Werner Braun Journal: J Mol Model Date: 2006-04-11 Impact factor: 1.810
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Authors: Catherine H Schein; David M Bowen; Jessica A Lewis; Kyung Choi; Aniko Paul; Gerbrand J van der Heden van Noort; Wenzhe Lu; Dmitri V Filippov Journal: BMC Bioinformatics Date: 2012-08-24 Impact factor: 3.169
Authors: Stanley A Langevin; Richard A Bowen; William K Reisen; Christy C Andrade; Wanichaya N Ramey; Payal D Maharaj; Michael Anishchenko; Joan L Kenney; Nisha K Duggal; Hannah Romo; Aloke Kumar Bera; Todd A Sanders; Angela Bosco-Lauth; Janet L Smith; Richard Kuhn; Aaron C Brault Journal: PLoS One Date: 2014-06-27 Impact factor: 3.240