| Literature DB >> 20223736 |
Petr Danecek1, Catherine H Schein.
Abstract
The Flavitrack database groups Flaviviruses (FV), evolutionarily related organisms with high subtype variability, according to their phenotypes. Here, PCPMer tools were used to calculate consensus sequences based on conservation of Physicochemical Properties (PCP) for 919 sequences of NS2a, a non-structural protein involved in preventing host interferon response to infection. Conserved PCP-motifs were detected, primarily in the N-terminal half of NS2a. One model structure, based on a nuclear receptor, groups residues essential for West Nile (WN) infectivity (I59, V61, and M103) in a pocket on the protein surface. These methods will aid in the design of vaccines and specific therapies against FV.Entities:
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Year: 2010 PMID： 20223736 PMCID： PMC2849288 DOI： 10.1504/IJBRA.2010.032117
Source DB: PubMed Journal: Int J Bioinform Res Appl ISSN： 1744-5485