Literature DB >> 17652026

Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening.

Larry A Sklar1, Mark B Carter, Bruce S Edwards.   

Abstract

Although flow cytometry is viewed as a mature technology, there have been dramatic advances in analysis capabilities, sorting, sample handling and sensitivity in the past decade. These advances contribute to its application in biological and chemical diversity, sample throughput, high content, and complex systems biology. This article will evaluate the new opportunities for flow cytometry relating to receptor assembly and pharmacology, as well as a range of screening applications.

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Year:  2007        PMID： 17652026      PMCID： PMC2230635          DOI： 10.1016/j.coph.2007.06.006

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  41 in total

1.  Suspension array technology: evolution of the flat-array paradigm.

Authors:  John P Nolan; Larry A Sklar
Journal:  Trends Biotechnol       Date:  2002-01       Impact factor: 19.536

Review 2.  Flow cytometric analysis of ligand-receptor interactions and molecular assemblies.

Authors:  Larry A Sklar; Bruce S Edwards; Steven W Graves; John P Nolan; Eric R Prossnitz
Journal:  Annu Rev Biophys Biomol Struct       Date:  2001-10-25

3.  Flow cytometry: a versatile tool for all phases of drug discovery.

Authors: 
Journal:  Drug Discov Today       Date:  1999-04       Impact factor: 7.851

Review 4.  Multiplexed microsphere-based flow cytometric assays.

Authors:  Kathryn L Kellar; Marie A Iannone
Journal:  Exp Hematol       Date:  2002-11       Impact factor: 3.084

5.  Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.

Authors:  Peter O Krutzik; Garry P Nolan
Journal:  Cytometry A       Date:  2003-10       Impact factor: 4.355

6.  A transmembrane intracellular estrogen receptor mediates rapid cell signaling.

Authors:  Chetana M Revankar; Daniel F Cimino; Larry A Sklar; Jeffrey B Arterburn; Eric R Prossnitz
Journal:  Science       Date:  2005-02-10       Impact factor: 47.728

Review 7.  Can cell systems biology rescue drug discovery?

Authors:  Eugene C Butcher
Journal:  Nat Rev Drug Discov       Date:  2005-06       Impact factor: 84.694

Review 8.  Multiplexed and microparticle-based analyses: quantitative tools for the large-scale analysis of biological systems.

Authors:  John P Nolan; Francis Mandy
Journal:  Cytometry A       Date:  2006-05       Impact factor: 4.355

9.  A simple and powerful flow cytometric method for the simultaneous determination of multiple parameters at G protein-coupled receptor subtypes.

Authors:  Erich Schneider; Matthias Mayer; Ralf Ziemek; Liantao Li; Christoph Hutzler; Günther Bernhardt; Armin Buschauer
Journal:  Chembiochem       Date:  2006-09       Impact factor: 3.164

10.  Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging.

Authors:  Li Peng; Ruiwu Liu; Jan Marik; Xiaobing Wang; Yoshikazu Takada; Kit S Lam
Journal:  Nat Chem Biol       Date:  2006-06-11       Impact factor: 15.040
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  17 in total

1.  Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.

Authors:  Jun Chen; Susan M Young; Chris Allen; Andrew Seeber; Marie-Pierre Péli-Gulli; Nicolas Panchaud; Anna Waller; Oleg Ursu; Tuanli Yao; Jennifer E Golden; J Jacob Strouse; Mark B Carter; Huining Kang; Cristian G Bologa; Terry D Foutz; Bruce S Edwards; Blake R Peterson; Jeffrey Aubé; Margaret Werner-Washburne; Robbie J Loewith; Claudio De Virgilio; Larry A Sklar
Journal:  ACS Chem Biol       Date:  2012-02-01       Impact factor: 5.100

2.  High throughput flow cytometry based yeast two-hybrid array approach for large-scale analysis of protein-protein interactions.

Authors:  Jun Chen; Mark B Carter; Bruce S Edwards; Hong Cai; Larry A Sklar
Journal:  Cytometry A       Date:  2011-09-27       Impact factor: 4.355

3.  Imaging and Functional Analysis of γ-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe.

Authors:  M Lane Gilchrist; Kwangwook Ahn; Yue-Ming Li
Journal:  Anal Chem       Date:  2016-01-06       Impact factor: 6.986

4.  The University of New Mexico Center for Molecular Discovery.

Authors:  Bruce S Edwards; Kristine Gouveia; Tudor I Oprea; Larry A Sklar
Journal:  Comb Chem High Throughput Screen       Date:  2014-03       Impact factor: 1.339

Review 5.  Cell-based assays for high-throughput screening.

Authors:  W Frank An; Nicola Tolliday
Journal:  Mol Biotechnol       Date:  2010-06       Impact factor: 2.695

6.  Genetic barcoding with fluorescent proteins for multiplexed applications.

Authors:  Cameron A Smurthwaite; Wesley Williams; Alexandra Fetsko; Darin Abbadessa; Zachary D Stolp; Connor W Reed; Andre Dharmawan; Roland Wolkowicz
Journal:  J Vis Exp       Date:  2015-04-14       Impact factor: 1.355

Review 7.  Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases.

Authors:  Kelly M Haston; Steven Finkbeiner
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-10-28       Impact factor: 13.820

Review 8.  Institutional shared resources and translational cancer research.

Authors:  Paolo De Paoli
Journal:  J Transl Med       Date:  2009-06-29       Impact factor: 5.531

9.  High-throughput secondary screening at the single-cell level.

Authors:  J Paul Robinson; Valery Patsekin; Cheryl Holdman; Kathy Ragheb; Jennifer Sturgis; Ray Fatig; Larisa V Avramova; Bartek Rajwa; V Jo Davisson; Nicole Lewis; Padma Narayanan; Nianyu Li; C W Qualls
Journal:  J Lab Autom       Date:  2012-09-10

10.  Conformational mAb as a tool for integrin ligand discovery.

Authors:  Ben H Njus; Alexandre Chigaev; Anna Waller; Danuta Wlodek; Liliana Ostopovici-Halip; Oleg Ursu; Wei Wang; Tudor I Oprea; Cristian G Bologa; Larry A Sklar
Journal:  Assay Drug Dev Technol       Date:  2009-10       Impact factor: 1.738
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