Literature DB >> 10322276

Flow cytometry: a versatile tool for all phases of drug discovery.

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Abstract

The applications of flow cytometry are being extended beyond cells into molecular interactions and genomic analyses. The authors explain how instrumentation and reagent development are combining to improve flow cytometric throughput by orders of magnitude beyond that possible just a few years ago, such that the combination of sensitivity, throughput and versatility makes flow cytometry an analytical platform with applications at all stages of drug discovery.

Year:  1999        PMID: 10322276     DOI: 10.1016/S1359-6446(99)01320-3

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  6 in total

Review 1.  Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening.

Authors:  Larry A Sklar; Mark B Carter; Bruce S Edwards
Journal:  Curr Opin Pharmacol       Date:  2007-07-24       Impact factor: 5.547

2.  Elastomeric negative acoustic contrast particles for affinity capture assays.

Authors:  Kevin W Cushing; Menake E Piyasena; Nick J Carroll; Gian C Maestas; Beth Ann López; Bruce S Edwards; Steven W Graves; Gabriel P López
Journal:  Anal Chem       Date:  2013-02-05       Impact factor: 6.986

3.  Chapter 11. Subsecond analyses of G-protein coupled-receptor ternary complex dynamics by rapid mix flow cytometry.

Authors:  Tione Buranda; Yang Wu; Larry A Sklar
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

4.  Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes.

Authors:  Andrew D Skora; Jacqueline Douglass; Michael S Hwang; Ada J Tam; Richard L Blosser; Sandra B Gabelli; Jianhong Cao; Luis A Diaz; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Shibin Zhou
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-27       Impact factor: 11.205

5.  DNA-directed assembly of antibody-fluorophore conjugates for quantitative multiparametric flow cytometry.

Authors:  Amy C Flor; Jimmy H Williams; Kelly M Blaine; Ryan C Duggan; Anne I Sperling; David A Schwartz; Stephen J Kron
Journal:  Chembiochem       Date:  2013-12-27       Impact factor: 3.164

Review 6.  Porous bead-based diagnostic platforms: bridging the gaps in healthcare.

Authors:  Jie Chou; Jorge Wong; Nicolaos Christodoulides; Pierre N Floriano; Ximena Sanchez; John McDevitt
Journal:  Sensors (Basel)       Date:  2012-11-09       Impact factor: 3.576

  6 in total

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