Literature DB >> 6595660

alpha-Amanitin-insensitive transcription of mouse beta major-globin 5'-flanking and structural gene sequences correlates with mRNA expression.

D P Carlson, J Ross.   

Abstract

A small proportion of the RNAs of mouse reticulocytes consists of beta major-globin mRNA sequences linked to sequences transcribed from the 5'-flanking region of the beta major-globin gene. These upstream RNAs are polyadenylylated and contain 700-800 nucleotides, and their 5' regions are heterogeneous. RNAs with similar or identical 5' regions are transcribed in cell-free extracts from a circular mouse beta major-globin gene template. Synthesis of most of the upstream RNAs in vitro is not inhibited by low levels (1 microgram/ml) of alpha-amanitin, indicating that they are transcribed by an enzyme(s) different from RNA polymerase II. During culture of mouse erythroleukemia cells with dimethyl sulfoxide, globin mRNA and upstream RNAs accumulate with similar kinetics. In contrast, upstream RNAs are not detected in hemin-treated cells.

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Year:  1984        PMID： 6595660      PMCID： PMC392236          DOI： 10.1073/pnas.81.24.7782

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  A precursor of globin messenger RNA.

Authors:  J Ross
Journal:  J Mol Biol       Date:  1976-09-15       Impact factor: 5.469

2.  Globin gene expression in cultured erythroleukemic cells.

Authors:  J Ross; J Gielen; S Packman; Y Ikawa; P Leder
Journal:  J Mol Biol       Date:  1974-08-25       Impact factor: 5.469

3.  Ribonucleic acid isolated by cesium chloride centrifugation.

Authors:  V Glisin; R Crkvenjakov; C Byus
Journal:  Biochemistry       Date:  1974-06-04       Impact factor: 3.162

4.  Preparation, molecular weight, base composition, and secondary structure of giant nuclear ribonucleic acid.

Authors:  D S Holmes; J Bonner
Journal:  Biochemistry       Date:  1973-06-05       Impact factor: 3.162

5.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

6.  Multiple initiation and polyadenylation sites for the chicken ovomucoid transcription unit.

Authors:  P Gerlinger; A Krust; M LeMeur; F Perrin; M Cochet; F Gannon; D Dupret; P Chambon
Journal:  J Mol Biol       Date:  1982-12-05       Impact factor: 5.469

7.  Heterogeneous initiation regions for transcription of the chicken ovomucoid gene.

Authors:  E C Lai; D R Roop; M J Tsai; S L Woo; B W O'Malley
Journal:  Nucleic Acids Res       Date:  1982-09-25       Impact factor: 16.971

8.  Epsilon globin gene transcripts originating upstream of the mRNA cap site in K562 cells and normal human embryos.

Authors:  M Alan; G J Grindlay; L Stefani; J Paul
Journal:  Nucleic Acids Res       Date:  1982-09-11       Impact factor: 16.971

9.  Alterations in globin gene chromatin conformation during murine erythroleukemia cell differentiation.

Authors:  R D Smith; J Yu
Journal:  J Biol Chem       Date:  1984-04-10       Impact factor: 5.157

10.  Isolation and partial characterization of the Drosophila alcohol dehydrogenase gene.

Authors:  D A Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205
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  13 in total

Review 1.  Fifty years of amanitin.

Authors:  T Wieland; H Faulstich
Journal:  Experientia       Date:  1991-12-01

2.  Point mutation associated with hereditary persistence of fetal hemoglobin decreases RNA polymerase III transcription upstream of the affected gamma-globin gene.

Authors:  D P Carlson; J Ross
Journal:  Mol Cell Biol       Date:  1986-09       Impact factor: 4.272

Review 3.  Reverse transcriptase: mediator of genomic plasticity.

Authors:  J Brosius; H Tiedge
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

4.  RNA processing of beta-globin transcripts containing 5' flanking and structural gene sequences.

Authors:  I Winicov
Journal:  Nucleic Acids Res       Date:  1988-01-25       Impact factor: 16.971

5.  Alpha-amanitin insensitive transcription of the human epsilon-globin gene.

Authors:  G Kollias; C E Sekeris; F G Grosveld
Journal:  Nucleic Acids Res       Date:  1985-11-25       Impact factor: 16.971

6.  RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

Authors:  M B Soares; E Schon; A Henderson; S K Karathanasis; R Cate; S Zeitlin; J Chirgwin; A Efstratiadis
Journal:  Mol Cell Biol       Date:  1985-08       Impact factor: 4.272

7.  Structural and transcriptional analysis of DNA sequences flanking genes that encode 19 kilodalton zeins.

Authors:  A L Kriz; R S Boston; B A Larkins
Journal:  Mol Gen Genet       Date:  1987-04

8.  Changes in minor transcripts from the alpha 1 and beta maj globin and glutathione peroxidase genes during erythropoiesis.

Authors:  J Frampton; D Conkie; I Chambers; W McBain; M Dexter; P Harrison
Journal:  Nucleic Acids Res       Date:  1987-05-11       Impact factor: 16.971

9.  RNA polymerase specificity of mRNA production and enhancer action.

Authors:  M A Lopata; D W Cleveland; B Sollner-Webb
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

10.  Minor transcription initiation events indicate that both human mitochondrial promoters function bidirectionally.

Authors:  D D Chang; J E Hixson; D A Clayton
Journal:  Mol Cell Biol       Date:  1986-01       Impact factor: 4.272
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