Literature DB >> 17646137

Validated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethamphetamine in squirrel monkey plasma.

Melanie Mueller1, Frank T Peters, George A Ricaurte, Hans H Maurer.   

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) is a recreational drug with neurotoxic potential. Pharmacokinetic data of MDMA and its metabolites may shed light on the mechanism of MDMA neurotoxicity. An LC-MS assay with electrospray ionization (ESI) is presented for quantifying MDMA and its metabolites 3,4-methylenedioxyamphetamine (MDA), 3,4-dihydroxymethamphetamine (HHMA), and 4-hydroxy-3-methoxymethamphetamine (HMMA) in squirrel monkey plasma. The method involved enzymatic conjugate cleavage and protein precipitation. Separation was achieved within 14min. The method was validated according to international guidelines with respect to selectivity, linearity, accuracy, precision, recovery, and matrix effect. The present method should prove useful for acquiring pharmacokinetic and toxicokinetic data in squirrel monkeys.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17646137      PMCID： PMC2682589          DOI： 10.1016/j.jchromb.2007.06.034

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  27 in total

1.  Bioanalytical method validation--a revisit with a decade of progress.

Authors:  V P Shah; K K Midha; J W Findlay; H M Hill; J D Hulse; I J McGilveray; G McKay; K J Miller; R N Patnaik; M L Powell; A Tonelli; C T Viswanathan; A Yacobi
Journal:  Pharm Res       Date:  2000-12       Impact factor: 4.200

2.  3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose.

Authors:  B Esteban; E O'Shea; J Camarero; V Sanchez; A R Green; M I Colado
Journal:  Psychopharmacology (Berl)       Date:  2001-03       Impact factor: 4.530

Review 3.  Hyphenated mass spectrometric techniques-indispensable tools in clinical and forensic toxicology and in doping control.

Authors:  Hans H Maurer
Journal:  J Mass Spectrom       Date:  2006-11       Impact factor: 1.982

4.  Analytical toxicology.

Authors:  Hans H Maurer
Journal:  Anal Bioanal Chem       Date:  2007-08       Impact factor: 4.142

5.  3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans.

Authors:  M Segura; J Ortuño; M Farré; J A McLure; M Pujadas; N Pizarro; A Llebaria; J Joglar; P N Roset; J Segura; R de La Torre
Journal:  Chem Res Toxicol       Date:  2001-09       Impact factor: 3.739

6.  Reaction of oxygen with 6-hydroxydopamine catalyzed by Cu, Fe, Mn, and V complexes: identification of a thermodynamic window for effective metal catalysis.

Authors:  B Bandy; P B Walter; J Moon; A J Davison
Journal:  Arch Biochem Biophys       Date:  2001-05-01       Impact factor: 4.013

Review 7.  Amphetamines: an update on forensic issues.

Authors:  B K Logan
Journal:  J Anal Toxicol       Date:  2001 Jul-Aug       Impact factor: 3.367

8.  Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs ('Ecstasy').

Authors:  H H Maurer; J Bickeboeller-Friedrich; T Kraemer; F T Peters
Journal:  Toxicol Lett       Date:  2000-03-15       Impact factor: 4.372

9.  Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity.

Authors:  F Bai; S S Lau; T J Monks
Journal:  Chem Res Toxicol       Date:  1999-12       Impact factor: 3.739

Review 10.  Ecstasy: are animal data consistent between species and can they translate to humans?

Authors:  Neil Easton; Charles A Marsden
Journal:  J Psychopharmacol       Date:  2006-03       Impact factor: 4.153
View more
  9 in total

1.  Metabolism and disposition of 3,4-methylenedioxymethamphetamine ("ecstasy") in baboons after oral administration: comparison with humans reveals marked differences.

Authors:  Melanie Mueller; Amy K Goodwin; Nancy A Ator; Una D McCann; George A Ricaurte
Journal:  J Pharmacol Exp Ther       Date:  2011-04-14       Impact factor: 4.030

2.  Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity.

Authors:  Melanie Mueller; Jie Yuan; Concepcion Maldonado Adrian; Una D McCann; George A Ricaurte
Journal:  Synapse       Date:  2011-03-28       Impact factor: 2.562

3.  Hydrolysis of 3,4-methylenedioxymethamphetamine (MDMA) metabolite conjugates in human, squirrel monkey, and rat plasma.

Authors:  Melanie Mueller; Erin A Kolbrich-Spargo; Frank T Peters; Marilyn A Huestis; George A Ricaurte; Hans H Maurer
Journal:  Anal Bioanal Chem       Date:  2009-01-30       Impact factor: 4.142

4.  Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.

Authors:  Melanie Mueller; Jie Yuan; Anne Felim; Anne Neudörffer; Frank T Peters; Hans H Maurer; Una D McCann; Martine Largeron; George A Ricaurte
Journal:  Drug Metab Dispos       Date:  2009-07-23       Impact factor: 3.922

5.  Studies of (±)-3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profile.

Authors:  Melanie Mueller; Concepcion Maldonado-Adrian; Jie Yuan; Una D McCann; George A Ricaurte
Journal:  J Pharmacol Exp Ther       Date:  2012-12-03       Impact factor: 4.030

6.  Simultaneous liquid chromatographic-electrospray ionization mass spectrometric quantification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its metabolites 3,4-dihydroxymethamphetamine, 4-hydroxy-3-methoxymethamphetamine and 3,4-methylenedioxyamphetamine in squirrel monkey and human plasma after acidic conjugate cleavage.

Authors:  Melanie Mueller; Frank T Peters; Marilyn A Huestis; George A Ricaurte; Hans H Maurer
Journal:  Forensic Sci Int       Date:  2009-01-07       Impact factor: 2.395

7.  Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat.

Authors:  Marta Concheiro; Michael H Baumann; Karl B Scheidweiler; Richard B Rothman; Gina F Marrone; Marilyn A Huestis
Journal:  Drug Metab Dispos       Date:  2013-10-18       Impact factor: 3.922

8.  A validated gas chromatographic-electron impact ionization mass spectrometric method for methamphetamine, methylenedioxymethamphetamine (MDMA), and metabolites in mouse plasma and brain.

Authors:  Karl B Scheidweiler; Allan J Barnes; Marilyn A Huestis
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2008-11-07       Impact factor: 3.205

9.  3,4-Methylenedioxypyrovalerone (MDPV) and metabolites quantification in human and rat plasma by liquid chromatography-high resolution mass spectrometry.

Authors:  Sebastien Anizan; Kayla Ellefsen; Marta Concheiro; Masaki Suzuki; Kenner C Rice; Michael H Baumann; Marilyn A Huestis
Journal:  Anal Chim Acta       Date:  2014-04-12       Impact factor: 6.558
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.