Literature DB >> 19026602

A validated gas chromatographic-electron impact ionization mass spectrometric method for methamphetamine, methylenedioxymethamphetamine (MDMA), and metabolites in mouse plasma and brain.

Karl B Scheidweiler1, Allan J Barnes, Marilyn A Huestis.   

Abstract

A method was developed and fully validated for simultaneous quantification of methamphetamine (MAMP), amphetamine, hydroxy-methamphetamine, methylenedioxymethamphetamine (MDMA, ecstasy), methylenedioxyamphetamine, 3-hydroxy-4-methoxy-methamphetamine, and 3-hydroxy-4-methoxy-amphetamine in 100 microL mouse plasma and 7.5mg brain. Solid phase extraction and gas chromatography-electron impact ionization mass spectrometry in selected-ion monitoring mode achieved plasma linear ranges of 10-20 to 20,000 ng/mL and 0.1-0.2 to 200 ng/mg in brain. Recoveries were greater than 91%, bias 92.3-110.4%, and imprecision less than 5.3% coefficient of variation. This method was used for measuring MAMP and MDMA and metabolites in plasma and brain during mouse neurotoxicity studies.

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Year:  2008        PMID： 19026602      PMCID： PMC2607242          DOI： 10.1016/j.jchromb.2008.11.001

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  51 in total

1.  Determination of drugs of abuse and their metabolites in human plasma by liquid chromatography-mass spectrometry. An application to 156 road fatalities.

Authors:  Marta Concheiro; Ana de Castro; Oscar Quintela; Manuel López-Rivadulla; Angelines Cruz
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2006-01-24       Impact factor: 3.205

2.  Drug testing in blood: validated negative-ion chemical ionization gas chromatographic-mass spectrometric assay for enantioselective measurement of the designer drugs MDEA, MDMA, and MDA and its application to samples from a controlled study with MDMA.

Authors:  Frank T Peters; Nele Samyn; Caroline T J Lamers; Wim J Riedel; Thomas Kraemer; Gert de Boeck; Hans H Maurer
Journal:  Clin Chem       Date:  2005-08-11       Impact factor: 8.327

3.  A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice.

Authors:  Isabel Escobedo; Esther O'Shea; Laura Orio; Veronica Sanchez; Mireia Segura; Rafael de la Torre; Magi Farre; Alfred Richard Green; Maria Isabel Colado
Journal:  Br J Pharmacol       Date:  2005-01       Impact factor: 8.739

4.  Ecstasy (MDMA, MDA, MDEA, MBDB) consumption, seizures, related offences, prices, dosage levels and deaths in the UK (1994-2003).

Authors:  Fabrizio Schifano; John Corkery; Paolo Deluca; Adenekan Oyefeso; A Hamid Ghodse
Journal:  J Psychopharmacol       Date:  2006-05       Impact factor: 4.153

5.  Quantification of 3,4-methylenedioxymetamphetamine and its metabolites in plasma and urine by gas chromatography with nitrogen-phosphorus detection.

Authors:  J Ortuño; N Pizarro; M Farré; M Mas; J Segura; J Camí; R Brenneisen; R de la Torre
Journal:  J Chromatogr B Biomed Sci Appl       Date:  1999-02-19

6.  Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity.

Authors:  Y Itzhak; C Gandia; P L Huang; S F Ali
Journal:  J Pharmacol Exp Ther       Date:  1998-03       Impact factor: 4.030

7.  Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.

Authors:  D Bengel; D L Murphy; A M Andrews; C H Wichems; D Feltner; A Heils; R Mössner; H Westphal; K P Lesch
Journal:  Mol Pharmacol       Date:  1998-04       Impact factor: 4.436

8.  Urinary excretion of the main metabolites of methamphetamine, including p-hydroxymethamphetamine-sulfate and p-hydroxymethamphetamine-glucuronide, in humans and rats.

Authors:  N Shima; H T Kamata; M Katagi; H Tsuchihashi
Journal:  Xenobiotica       Date:  2006 Feb-Mar       Impact factor: 1.908

9.  Comparison between the role of the neuronal and inducible nitric oxide synthase in methamphetamine-induced neurotoxicity and sensitization.

Authors:  Y Itzhak; J L Martin; S F Ali
Journal:  Ann N Y Acad Sci       Date:  2000-09       Impact factor: 5.691

10.  Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine.

Authors:  Y M Wang; R R Gainetdinov; F Fumagalli; F Xu; S R Jones; C B Bock; G W Miller; R M Wightman; M G Caron
Journal:  Neuron       Date:  1997-12       Impact factor: 17.173
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  3 in total

1.  3,4-Methylenedioxymethamphetamine (MDMA) and metabolites disposition in blood and plasma following controlled oral administration.

Authors:  Rebecca L Hartman; Nathalie A Desrosiers; Allan J Barnes; Keming Yun; Karl B Scheidweiler; Erin A Kolbrich-Spargo; David A Gorelick; Robert S Goodwin; Marilyn A Huestis
Journal:  Anal Bioanal Chem       Date:  2013-11-15       Impact factor: 4.142

2.  Mice lacking multidrug resistance protein 1a show altered dopaminergic responses to methylenedioxymethamphetamine (MDMA) in striatum.

Authors:  Karl B Scheidweiler; Bruce Ladenheim; Jean Lud Cadet; Marilyn A Huestis
Journal:  Neurotox Res       Date:  2009-10-23       Impact factor: 3.911

3.  Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat.

Authors:  Michael H Baumann; Dorota Zolkowska; Insook Kim; Karl B Scheidweiler; Richard B Rothman; Marilyn A Huestis
Journal:  Drug Metab Dispos       Date:  2009-08-13       Impact factor: 3.922
  3 in total

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