Literature DB >> 1763012

Chemical implementation of neural networks and Turing machines.

A Hjelmfelt1, E D Weinberger, J Ross.   

Abstract

We propose a reversible reaction mechanism with a single stationary state in which certain concentrations assume either high or low values dependent on the concentration of a catalyst. The properties of this mechanism are those of a McCulloch-Pitts neuron. We suggest a mechanism of interneuronal connections in which the stationary state of a chemical neuron is determined by the state of other neurons in a homogeneous chemical system and is thus a "hardware" chemical implementation of neural networks. Specific connections are determined for the construction of logic gates: AND, NOR, etc. Neural networks may be constructed in which the flow of time is continuous and computations are achieved by the attainment of a stationary state of the entire chemical reaction system, or in which the flow of time is discretized by an oscillatory reaction. In another article, we will give a chemical implementation of finite state machines and stack memories, with which in principle the construction of a universal Turing machine is possible.

Mesh:

Year:  1991        PMID: 1763012      PMCID: PMC53057          DOI: 10.1073/pnas.88.24.10983

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  10 in total

1.  Unpredictability and undecidability in dynamical systems.

Authors: 
Journal:  Phys Rev Lett       Date:  1990-05-14       Impact factor: 9.161

2.  Undecidability and intractability in theoretical physics.

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Journal:  Phys Rev Lett       Date:  1985-02-25       Impact factor: 9.161

3.  Superiority of interconvertible enzyme cascades in metabolic regulation: analysis of monocyclic systems.

Authors:  E R Stadtman; P B Chock
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

4.  Computing with neural circuits: a model.

Authors:  J J Hopfield; D W Tank
Journal:  Science       Date:  1986-08-08       Impact factor: 47.728

5.  Switching mechanism of a cyclic enzyme system: role as a "chemical diode".

Authors:  M Okamoto; T Sakai; K Hayashi
Journal:  Biosystems       Date:  1987       Impact factor: 1.973

6.  Biochemical switching device realizing McCulloch-Pitts type equation.

Authors:  M Okamoto; T Sakai; K Hayashi
Journal:  Biol Cybern       Date:  1988       Impact factor: 2.086

7.  Dynamic behavior of cyclic enzyme systems.

Authors:  M Okamoto; K Hayashi
Journal:  J Theor Biol       Date:  1983-10-21       Impact factor: 2.691

8.  Neural networks and physical systems with emergent collective computational abilities.

Authors:  J J Hopfield
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

9.  Dynamic behavior of enzymatic system realizing two-factor model.

Authors:  M Okamoto; A Katsurayama; M Tsukiji; Y Aso; K Hayashi
Journal:  J Theor Biol       Date:  1980-03-07       Impact factor: 2.691

10.  Neurons with graded response have collective computational properties like those of two-state neurons.

Authors:  J J Hopfield
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

  10 in total
  43 in total

1.  Chemical implementation of finite-state machines.

Authors:  A Hjelmfelt; E D Weinberger; J Ross
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

2.  Boolean logic functions of a synthetic peptide network.

Authors:  Gonen Ashkenasy; M Reza Ghadiri
Journal:  J Am Chem Soc       Date:  2004-09-15       Impact factor: 15.419

Review 3.  Reaction-diffusion systems in intracellular molecular transport and control.

Authors:  Siowling Soh; Marta Byrska; Kristiana Kandere-Grzybowska; Bartosz A Grzybowski
Journal:  Angew Chem Int Ed Engl       Date:  2010-06-07       Impact factor: 15.336

4.  Distributed biological computation with multicellular engineered networks.

Authors:  Sergi Regot; Javier Macia; Núria Conde; Kentaro Furukawa; Jimmy Kjellén; Tom Peeters; Stefan Hohmann; Eulàlia de Nadal; Francesc Posas; Ricard Solé
Journal:  Nature       Date:  2010-12-08       Impact factor: 49.962

5.  Chemical implementation and thermodynamics of collective neural networks.

Authors:  A Hjelmfelt; J Ross
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

6.  The potential for signal integration and processing in interacting MAP kinase cascades.

Authors:  John H Schwacke; Eberhard O Voit
Journal:  J Theor Biol       Date:  2007-01-14       Impact factor: 2.691

7.  Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme.

Authors:  Nathan C Gianneschi; M Reza Ghadiri
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

8.  Configurable NOR gate arrays from Belousov-Zhabotinsky micro-droplets.

Authors:  A L Wang; J M Gold; N Tompkins; M Heymann; K I Harrington; S Fraden
Journal:  Eur Phys J Spec Top       Date:  2016-02-29       Impact factor: 2.707

Review 9.  Biocomputers: from test tubes to live cells.

Authors:  Yaakov Benenson
Journal:  Mol Biosyst       Date:  2009-04-15

10.  A model of excitation and adaptation in bacterial chemotaxis.

Authors:  D C Hauri; J Ross
Journal:  Biophys J       Date:  1995-02       Impact factor: 4.033

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