OBJECTIVE: Recent studies suggest a lower risk for overweight/obesity in moderate alcohol drinkers. However, the validity of this relationship and its impact on the putative benefits of alcohol consumption on cardiovascular disease (CVD) risk has not been well evaluated. RESEARCH DESIGN AND METHODS: We assessed the impact of BMI on the relationship between alcohol consumption and CVD risk factors (blood pressure, lipid panel, and glucose and insulin concentrations) in 27,030 healthy Korean men with no major comorbidities or medication intake seen in a large urban Korean hospital. RESULTS: BMI and overweight prevalence increased linearly with alcohol intake (P < 0.001). Alcohol intake was also positively associated with blood pressure and triglyceride, HDL, and fasting glucose concentrations (P < 0.001) and negatively associated with LDL and insulin concentrations (P < 0.001). With nondrinkers as the reference group, the odds ratio for having insulin in the top quartile also declined linearly when adjusted for age, BMI, smoking, and exercise, with the heaviest drinkers (>40 g/day) having an odds ratio of 0.71 (95% CI 0.62-0.82) (P < 0.001). The relationship between alcohol and CVD risk factors was similar in normal-weight and overweight individuals. CONCLUSIONS: Alcohol intake is associated with increasing BMI and several metabolic abnormalities, including higher fasting glucose. Paradoxically, it is also associated with lower insulin concentrations. The clinical significance of these findings needs further investigation.
OBJECTIVE: Recent studies suggest a lower risk for overweight/obesity in moderate alcohol drinkers. However, the validity of this relationship and its impact on the putative benefits of alcohol consumption on cardiovascular disease (CVD) risk has not been well evaluated. RESEARCH DESIGN AND METHODS: We assessed the impact of BMI on the relationship between alcohol consumption and CVD risk factors (blood pressure, lipid panel, and glucose and insulin concentrations) in 27,030 healthy Korean men with no major comorbidities or medication intake seen in a large urban Korean hospital. RESULTS: BMI and overweight prevalence increased linearly with alcohol intake (P < 0.001). Alcohol intake was also positively associated with blood pressure and triglyceride, HDL, and fasting glucose concentrations (P < 0.001) and negatively associated with LDL and insulin concentrations (P < 0.001). With nondrinkers as the reference group, the odds ratio for having insulin in the top quartile also declined linearly when adjusted for age, BMI, smoking, and exercise, with the heaviest drinkers (>40 g/day) having an odds ratio of 0.71 (95% CI 0.62-0.82) (P < 0.001). The relationship between alcohol and CVD risk factors was similar in normal-weight and overweight individuals. CONCLUSIONS:Alcohol intake is associated with increasing BMI and several metabolic abnormalities, including higher fasting glucose. Paradoxically, it is also associated with lower insulin concentrations. The clinical significance of these findings needs further investigation.
Authors: John B Whitfield; Andrew C Heath; Pamela A F Madden; Michele L Pergadia; Grant W Montgomery; Nicholas G Martin Journal: Alcohol Clin Exp Res Date: 2012-11-07 Impact factor: 3.455
Authors: Margit Kaldmäe; Mihkel Zilmer; Margus Viigimaa; Galina Zemtsovskaja; Karel Tomberg; Tanel Kaart; Margus Annuk Journal: Ups J Med Sci Date: 2011-06-22 Impact factor: 2.384
Authors: Shreela V Sharma; Jill A Bush; Andrew J Lorino; Mark Knoblauch; Diana Abuamer; Gabe Blog; Dave Bertman Journal: J Int Soc Sports Nutr Date: 2008-04-18 Impact factor: 5.150
Authors: Sung Il Park; Young Gyu Cho; Jae Heon Kang; Hyun Ah Park; Kyoung Woo Kim; Yang Im Hur; Hye Jin Kang Journal: Korean J Fam Med Date: 2013-11-25