BACKGROUND: KIAA0319 (6p22.2) has recently been implicated as a susceptibility gene for dyslexia. We aimed to find further support for this gene by examining its association with reading and spelling ability in adolescent twins and their siblings unselected for dyslexia. METHODS: Ten single nucleotide polymorphisms (SNPs) in or near the KIAA0319 gene were typed in 440 families with up to five offspring who had been tested on reading and spelling tasks. Family-based association analyses were performed, including a univariate analysis of the principal component reading and spelling score derived from the Components of Reading Examination (CORE) test battery and a bivariate analysis of whole-word reading tests measured in a slightly larger sample. RESULTS: Significant association with rs2143340 (TTRAP) and rs6935076 (KIAA0319) and with a three-SNP haplotype spanning KIAA0319 and TTRAP was observed. The association with rs2143340 was found in both analyses, although the effect was in the opposite direction to that previously reported. The effect of rs6935076 on the principal component was in the same direction as past findings. Two of the three significant individual haplotypes showed effects in the opposite direction to the two prior reports. CONCLUSIONS: These results suggest that a multilocus effect in or near KIAA0319 may influence variation in reading ability.
BACKGROUND:KIAA0319 (6p22.2) has recently been implicated as a susceptibility gene for dyslexia. We aimed to find further support for this gene by examining its association with reading and spelling ability in adolescent twins and their siblings unselected for dyslexia. METHODS: Ten single nucleotide polymorphisms (SNPs) in or near the KIAA0319 gene were typed in 440 families with up to five offspring who had been tested on reading and spelling tasks. Family-based association analyses were performed, including a univariate analysis of the principal component reading and spelling score derived from the Components of Reading Examination (CORE) test battery and a bivariate analysis of whole-word reading tests measured in a slightly larger sample. RESULTS: Significant association with rs2143340 (TTRAP) and rs6935076 (KIAA0319) and with a three-SNP haplotype spanning KIAA0319 and TTRAP was observed. The association with rs2143340 was found in both analyses, although the effect was in the opposite direction to that previously reported. The effect of rs6935076 on the principal component was in the same direction as past findings. Two of the three significant individual haplotypes showed effects in the opposite direction to the two prior reports. CONCLUSIONS: These results suggest that a multilocus effect in or near KIAA0319 may influence variation in reading ability.
Authors: Caitlin E Szalkowski; Christopher G Fiondella; Albert M Galaburda; Glenn D Rosen; Joseph J Loturco; R Holly Fitch Journal: Int J Dev Neurosci Date: 2012-02-03 Impact factor: 2.457
Authors: Jessica Becker; Darina Czamara; Tom S Scerri; Franck Ramus; Valéria Csépe; Joel B Talcott; John Stein; Andrew Morris; Kerstin U Ludwig; Per Hoffmann; Ferenc Honbolygó; Dénes Tóth; Fabien Fauchereau; Caroline Bogliotti; Stéphanie Iannuzzi; Yves Chaix; Sylviane Valdois; Catherine Billard; Florence George; Isabelle Soares-Boucaud; Christophe-Loïc Gérard; Sanne van der Mark; Enrico Schulz; Anniek Vaessen; Urs Maurer; Kaisa Lohvansuu; Heikki Lyytinen; Marco Zucchelli; Daniel Brandeis; Leo Blomert; Paavo H T Leppänen; Jennifer Bruder; Anthony P Monaco; Bertram Müller-Myhsok; Juha Kere; Karin Landerl; Markus M Nöthen; Gerd Schulte-Körne; Silvia Paracchini; Myriam Peyrard-Janvid; Johannes Schumacher Journal: Eur J Hum Genet Date: 2013-09-11 Impact factor: 4.246
Authors: Jillian M Couto; Izzy Livne-Bar; Katherine Huang; Zhaodong Xu; Tasha Cate-Carter; Yu Feng; Karen Wigg; Tom Humphries; Rosemary Tannock; Elizabeth N Kerr; Maureen W Lovett; Rod Bremner; Cathy L Barr Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-03-05 Impact factor: 3.568