PURPOSE: To evaluate the efficacy of caspofungin in an experimental rabbit model of Fusarium keratitis and to compare it with amphotericin B. METHODS: Eighteen New Zealand white rabbits were randomly divided into 2 treatment groups and 1 control group. One cornea of each rabbit was inoculated with Fusarium solani spores. The first group received topical amphotericin B 0.15%, the second group received topical caspofungin 1%, and the control group received topical balanced salt solution hourly for 2 days and then 4 times daily for 3 additional days. Treatment effects were evaluated by clinical assessment at days 3 and 5 and by fungal culture after 5 days of treatment. RESULTS: In the treatment groups, progression of keratitis was inhibited, and cultures were sterile at the end of the study. In the control group, keratitis progressed, and cultures were positive for F. solani. CONCLUSIONS: Topical caspofungin is effective in Fusarium keratitis, and clinical efficacy studies seem justified.
PURPOSE: To evaluate the efficacy of caspofungin in an experimental rabbit model of Fusarium keratitis and to compare it with amphotericin B. METHODS: Eighteen New Zealand white rabbits were randomly divided into 2 treatment groups and 1 control group. One cornea of each rabbit was inoculated with Fusarium solani spores. The first group received topical amphotericin B 0.15%, the second group received topical caspofungin 1%, and the control group received topical balanced salt solution hourly for 2 days and then 4 times daily for 3 additional days. Treatment effects were evaluated by clinical assessment at days 3 and 5 and by fungal culture after 5 days of treatment. RESULTS: In the treatment groups, progression of keratitis was inhibited, and cultures were sterile at the end of the study. In the control group, keratitis progressed, and cultures were positive for F. solani. CONCLUSIONS: Topical caspofungin is effective in Fusarium keratitis, and clinical efficacy studies seem justified.
Authors: Chin Fen Neoh; Hui He; Jian Li; Robert O Fullinfaw; Lok Leung; Anant Misra; Rasik B Vajpayee; Geoffrey E Davies; Kay Stewart; David C M Kong Journal: Antimicrob Agents Chemother Date: 2010-07-26 Impact factor: 5.191
Authors: Chin Fen Neoh; Jovan Jacob; Lok Leung; Jian Li; Angela Stathopoulos; Kay Stewart; David C M Kong Journal: Antimicrob Agents Chemother Date: 2012-04-02 Impact factor: 5.191
Authors: Chin Fen Neoh; Lok Leung; Anant Misra; Rasik B Vajpayee; Geoffrey E Davies; Robert O Fullinfaw; Kay Stewart; David C M Kong Journal: Antimicrob Agents Chemother Date: 2011-01-24 Impact factor: 5.191
Authors: Thet Tun Aung; Wei Hong Jeff Chor; Myoe Naing Lynn; Anita Sook Yee Chan; Donald T H Tan; Roger W Beuerman Journal: Eye Contact Lens Date: 2020-09 Impact factor: 3.152