| Literature DB >> 20660672 |
Chin Fen Neoh1, Hui He, Jian Li, Robert O Fullinfaw, Lok Leung, Anant Misra, Rasik B Vajpayee, Geoffrey E Davies, Kay Stewart, David C M Kong.
Abstract
A rapid, precise, and sensitive liquid chromatography/mass spectrometry (LC/MS) method to quantify the caspofungin concentration in human aqueous humor was developed and validated. Sample preparation involved simple dilution of aqueous humor samples with acetonitrile. Azithromycin was the internal standard. Good linearity over 10 to 5,000 ng/ml was observed. The lower limit of quantification was 10 ng/ml. The intra- and interday accuracies (percent bias) were within 11%, while the intra- and interday precisions were within 6%.Entities:
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Year: 2010 PMID： 20660672 PMCID： PMC2944625 DOI： 10.1128/AAC.00509-10
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191