M Nilsson1, G von Wendt, P Wanger, L Martin. 1. Department of Clinical Neuroscience, Ophthalmology & Vision, Unit of Optometry, Karolinska Institutet, Box 8056, SE-10420 Stockholm, Sweden. maria.nilsson@ste.ki.se
Abstract
AIM: To evaluate central retinal thickness and foveal function using optical coherence tomography (OCT) and the Rarebit Fovea Test (RFT) in patients with diabetes without previously known retinopathy or maculopathy. METHOD: Forty-two patients with diabetes mellitus (DM) were selected from the screening records at St Erik Eye Hospital. Inclusion criteria were absence of macular or other retinal changes at previous screening examination and best corrected visual acuity >/=1.0. These patients and 42 healthy controls were examined with the recently developed RFT, and retinal thickness was measured using OCT. Lens thickness and light scatter were evaluated by Scheimpflug photography. RESULTS: Significantly more DM subjects (12/42) had a subnormal RFT result compared with the controls (2/42) (p = 0.007). None of the 12 DM subjects had maculopathy, one had mild non proliferative diabetic retinopathy, and five had minimal non-proliferative diabetic retinopathy. The retinal thickness in the pericentral zone was significantly (p<0.05) thinner in DM patients with subnormal RFT compared with the controls. CONCLUSION: Decreased RT and subnormal RFT results were found in a subgroup of diabetes patients, despite normal screening results. Prospective studies are under way to evaluate the prognostic implications.
AIM: To evaluate central retinal thickness and foveal function using optical coherence tomography (OCT) and the Rarebit Fovea Test (RFT) in patients with diabetes without previously known retinopathy or maculopathy. METHOD: Forty-two patients with diabetes mellitus (DM) were selected from the screening records at St Erik Eye Hospital. Inclusion criteria were absence of macular or other retinal changes at previous screening examination and best corrected visual acuity >/=1.0. These patients and 42 healthy controls were examined with the recently developed RFT, and retinal thickness was measured using OCT. Lens thickness and light scatter were evaluated by Scheimpflug photography. RESULTS: Significantly more DM subjects (12/42) had a subnormal RFT result compared with the controls (2/42) (p = 0.007). None of the 12 DM subjects had maculopathy, one had mild non proliferative diabetic retinopathy, and five had minimal non-proliferative diabetic retinopathy. The retinal thickness in the pericentral zone was significantly (p<0.05) thinner in DMpatients with subnormal RFT compared with the controls. CONCLUSION: Decreased RT and subnormal RFT results were found in a subgroup of diabetespatients, despite normal screening results. Prospective studies are under way to evaluate the prognostic implications.
Authors: Walter Makous; Joseph Carroll; Jessica I Wolfing; Julianna Lin; Nathan Christie; David R Williams Journal: Invest Ophthalmol Vis Sci Date: 2006-09 Impact factor: 4.799
Authors: Carine Biallosterski; Mirjam E J van Velthoven; Robert P J Michels; Reinier O Schlingemann; J Hans DeVries; Frank D Verbraak Journal: Br J Ophthalmol Date: 2007-03-23 Impact factor: 4.638
Authors: P Carpineto; L Toto; R Aloia; V Ciciarelli; E Borrelli; E Vitacolonna; M Di Nicola; L Di Antonio; R Mastropasqua Journal: Eye (Lond) Date: 2016-02-12 Impact factor: 3.775
Authors: Stephanie K Lynch; Kyungmoo Lee; Zhi Chen; James C Folk; Ursula Schmidt-Erfurth; Bianca S Gerendas; Andreas Wahle; Charles C Wykoff; Michael D Abràmoff Journal: Invest Ophthalmol Vis Sci Date: 2019-05-01 Impact factor: 4.799
Authors: Hille W van Dijk; Frank D Verbraak; Pauline H B Kok; Marilette Stehouwer; Mona K Garvin; Milan Sonka; J Hans DeVries; Reinier O Schlingemann; Michael D Abràmoff Journal: Invest Ophthalmol Vis Sci Date: 2012-05-14 Impact factor: 4.799
Authors: Hille W van Dijk; Frank D Verbraak; Marilette Stehouwer; Pauline H B Kok; Mona K Garvin; Milan Sonka; J Hans DeVries; Reinier O Schlingemann; Michael D Abràmoff Journal: Vision Res Date: 2010-08-27 Impact factor: 1.886
Authors: Hille W van Dijk; Frank D Verbraak; Pauline H B Kok; Mona K Garvin; Milan Sonka; Kyungmoo Lee; J Hans Devries; Robert P J Michels; Mirjam E J van Velthoven; Reinier O Schlingemann; Michael D Abràmoff Journal: Invest Ophthalmol Vis Sci Date: 2010-02-03 Impact factor: 4.799
Authors: Hille W van Dijk; Pauline H B Kok; Mona Garvin; Milan Sonka; J Hans Devries; Robert P J Michels; Mirjam E J van Velthoven; Reinier O Schlingemann; Frank D Verbraak; Michael D Abràmoff Journal: Invest Ophthalmol Vis Sci Date: 2009-01-17 Impact factor: 4.799