Literature DB >> 22282475

Epithelial nitration by a peroxidase/NOX5 system mediates mosquito antiplasmodial immunity.

Giselle de Almeida Oliveira1, Joshua Lieberman, Carolina Barillas-Mury.   

Abstract

Plasmodium ookinetes traverse midgut epithelial cells before they encounter the complement system in the mosquito hemolymph. We identified a heme peroxidase (HPX2) and NADPH oxidase 5 (NOX5) as critical mediators of midgut epithelial nitration and antiplasmodial immunity that enhance nitric oxide toxicity in Anopheles gambiae. We show that the two immune mechanisms that target ookinetes-epithelial nitration and thioester-containing protein 1 (TEP1)-mediated lysis-work sequentially, and we propose that epithelial nitration works as an opsonization-like system that promotes activation of the mosquito complement cascade.

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Year:  2012        PMID： 22282475      PMCID： PMC3444286          DOI： 10.1126/science.1209678

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  17 in total

1.  Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei: the time bomb theory of ookinete invasion of mosquitoes.

Authors:  Y S Han; J Thompson; F C Kafatos; C Barillas-Mury
Journal:  EMBO J       Date:  2000-11-15       Impact factor: 11.598

2.  8-Nitro-2'-deoxyguanosine, a specific marker of oxidation by reactive nitrogen species, is generated by the myeloperoxidase-hydrogen peroxide-nitrite system of activated human phagocytes.

Authors:  J Byun; J P Henderson; D M Mueller; J W Heinecke
Journal:  Biochemistry       Date:  1999-02-23       Impact factor: 3.162

3.  Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae.

Authors:  Stephanie Blandin; Shin-Hong Shiao; Luis F Moita; Chris J Janse; Andrew P Waters; Fotis C Kafatos; Elena A Levashina
Journal:  Cell       Date:  2004-03-05       Impact factor: 41.582

4.  Inducible peroxidases mediate nitration of anopheles midgut cells undergoing apoptosis in response to Plasmodium invasion.

Authors:  Sanjeev Kumar; Lalita Gupta; Yeon Soo Han; Carolina Barillas-Mury
Journal:  J Biol Chem       Date:  2004-09-29       Impact factor: 5.157

5.  Reactive oxygen species modulate Anopheles gambiae immunity against bacteria and Plasmodium.

Authors:  Alvaro Molina-Cruz; Randall J DeJong; Bradley Charles; Lalita Gupta; Sanjeev Kumar; Giovanna Jaramillo-Gutierrez; Carolina Barillas-Mury
Journal:  J Biol Chem       Date:  2007-12-06       Impact factor: 5.157

6.  Structural basis for conserved complement factor-like function in the antimalarial protein TEP1.

Authors:  Richard H G Baxter; Chung-I Chang; Yogarany Chelliah; Stéphanie Blandin; Elena A Levashina; Johann Deisenhofer
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-02       Impact factor: 11.205

7.  Structure-function analysis of the Anopheles gambiae LRIM1/APL1C complex and its interaction with complement C3-like protein TEP1.

Authors:  Michael Povelones; Leanna M Upton; Katarzyna A Sala; George K Christophides
Journal:  PLoS Pathog       Date:  2011-04-14       Impact factor: 6.823

8.  Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut.

Authors:  Shin-Hong Shiao; Miranda M A Whitten; Daniel Zachary; Jules A Hoffmann; Elena A Levashina
Journal:  PLoS Pathog       Date:  2006-12       Impact factor: 6.823

9.  Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes.

Authors:  Tsukasa Kawahara; Mark T Quinn; J David Lambeth
Journal:  BMC Evol Biol       Date:  2007-07-06       Impact factor: 3.260

10.  Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.

Authors:  Robert M Waterhouse; Evgenia V Kriventseva; Stephan Meister; Zhiyong Xi; Kanwal S Alvarez; Lyric C Bartholomay; Carolina Barillas-Mury; Guowu Bian; Stephanie Blandin; Bruce M Christensen; Yuemei Dong; Haobo Jiang; Michael R Kanost; Anastasios C Koutsos; Elena A Levashina; Jianyong Li; Petros Ligoxygakis; Robert M Maccallum; George F Mayhew; Antonio Mendes; Kristin Michel; Mike A Osta; Susan Paskewitz; Sang Woon Shin; Dina Vlachou; Lihui Wang; Weiqi Wei; Liangbiao Zheng; Zhen Zou; David W Severson; Alexander S Raikhel; Fotis C Kafatos; George Dimopoulos; Evgeny M Zdobnov; George K Christophides
Journal:  Science       Date:  2007-06-22       Impact factor: 47.728
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  87 in total

1.  Chemical depletion of phagocytic immune cells in Anopheles gambiae reveals dual roles of mosquito hemocytes in anti-Plasmodium immunity.

Authors:  Hyeogsun Kwon; Ryan C Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-24       Impact factor: 11.205

Review 2.  Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology.

Authors:  Christian Mitri; Kenneth D Vernick
Journal:  Curr Opin Microbiol       Date:  2012-04-24       Impact factor: 7.934

Review 3.  Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease.

Authors:  Peter D Crompton; Jacqueline Moebius; Silvia Portugal; Michael Waisberg; Geoffrey Hart; Lindsey S Garver; Louis H Miller; Carolina Barillas-Mury; Susan K Pierce
Journal:  Annu Rev Immunol       Date:  2014       Impact factor: 28.527

4.  Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae.

Authors:  Ryan C Smith; Carolina Barillas-Mury; Marcelo Jacobs-Lorena
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-15       Impact factor: 11.205

5.  Profile of Carolina Barillas-Mury.

Authors:  Paul Gabrielsen
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-31       Impact factor: 11.205

6.  Malaria parasite Pfs47 disrupts JNK signaling to escape mosquito immunity.

Authors:  Ryan C Smith; Marcelo Jacobs-Lorena
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-23       Impact factor: 11.205

7.  Activation of mosquito complement antiplasmodial response requires cellular immunity.

Authors:  Julio César Castillo; Ana Beatriz Barletta Ferreira; Nathanie Trisnadi; Carolina Barillas-Mury
Journal:  Sci Immunol       Date:  2017-01-20

8.  Some strains of Plasmodium falciparum, a human malaria parasite, evade the complement-like system of Anopheles gambiae mosquitoes.

Authors:  Alvaro Molina-Cruz; Randall J DeJong; Corrie Ortega; Ashley Haile; Ekua Abban; Janneth Rodrigues; Giovanna Jaramillo-Gutierrez; Carolina Barillas-Mury
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-23       Impact factor: 11.205

9.  Molecular Profiling of Phagocytic Immune Cells in Anopheles gambiae Reveals Integral Roles for Hemocytes in Mosquito Innate Immunity.

Authors:  Ryan C Smith; Jonas G King; Dingyin Tao; Oana A Zeleznik; Clara Brando; Gerhard G Thallinger; Rhoel R Dinglasan
Journal:  Mol Cell Proteomics       Date:  2016-09-13       Impact factor: 5.911

10.  HIV treatments have malaria gametocyte killing and transmission blocking activity.

Authors:  Charlotte V Hobbs; Takeshi Q Tanaka; Olga Muratova; Jillian Van Vliet; William Borkowsky; Kim C Williamson; Patrick E Duffy
Journal:  J Infect Dis       Date:  2013-03-28       Impact factor: 5.226
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