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Literature DB >> 17576415

One pathway, many products.

Abstract

Biosynthetic pathways for secondary metabolites usually make many products, not just one. In this Commentary, we consider why molecular promiscuity might be an evolutionarily advantageous feature of these pathways.

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Year: 2007 PMID： 17576415 DOI： 10.1038/nchembio0707-353

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

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Cited

49 in total

1. Chemistry and anatomy of the frontal gland in soldiers of the sand termite Psammotermes hybostoma.

Authors: Jana Krasulová; Robert Hanus; Kateřina Kutalová; Jan Šobotník; David Sillam-Dussès; Michal Tichý; Irena Valterová
Journal: J Chem Ecol Date: 2012-05-02 Impact factor: 2.626

2. Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.

Authors: Effendi Leonard; Parayil Kumaran Ajikumar; Kelly Thayer; Wen-Hai Xiao; Jeffrey D Mo; Bruce Tidor; Gregory Stephanopoulos; Kristala L J Prather
Journal: Proc Natl Acad Sci U S A Date: 2010-07-19 Impact factor: 11.205

Review 3. New insights into the formation of fungal aromatic polyketides.

Authors: Jason M Crawford; Craig A Townsend
Journal: Nat Rev Microbiol Date: 2010-12 Impact factor: 60.633

4. Assembly and clustering of natural antibiotics guides target identification.

Authors: Chad W Johnston; Michael A Skinnider; Chris A Dejong; Philip N Rees; Gregory M Chen; Chelsea G Walker; Shawn French; Eric D Brown; János Bérdy; Dennis Y Liu; Nathan A Magarvey
Journal: Nat Chem Biol Date: 2016-02-01 Impact factor: 15.040

5. Metabolic model for diversity-generating biosynthesis.

Authors: Ma Diarey Tianero; Elizabeth Pierce; Shrinivasan Raghuraman; Debosmita Sardar; John A McIntosh; John R Heemstra; Zachary Schonrock; Brett C Covington; J Alan Maschek; James E Cox; Brian O Bachmann; Baldomero M Olivera; Duane E Ruffner; Eric W Schmidt
Journal: Proc Natl Acad Sci U S A Date: 2016-02-01 Impact factor: 11.205

One pathway, many products.

1. Chemistry and anatomy of the frontal gland in soldiers of the sand termite Psammotermes hybostoma.

2. Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.

Review 3. New insights into the formation of fungal aromatic polyketides.

4. Assembly and clustering of natural antibiotics guides target identification.

5. Metabolic model for diversity-generating biosynthesis.

6. Informatic search strategies to discover analogues and variants of natural product archetypes.

Review 7. Two rings in them all: the labdane-related diterpenoids.

Review 8. Protein promiscuity and its implications for biotechnology.

9. Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria.

10. Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis.