| Literature DB >> 17562797 |
William R Kirkpatrick1, Laura K Najvar, Rosie Bocanegra, Thomas F Patterson, John R Graybill.
Abstract
We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with Cryptococcus neoformans responded to fluconazole and voriconazole. Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy.Entities:
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Year: 2007 PMID: 17562797 PMCID: PMC1932526 DOI: 10.1128/AAC.00085-07
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191