Literature DB >> 6364905

Experimental murine aspergillosis. Comparison of amphotericin B and a new polyene antifungal drug, SCH 28191.

J R Graybill, S R Kaster.   

Abstract

In a model of experimental murine aspergillosis, efficacy of amphotericin B (AMB) desoxycholate was compared with SCH 28191, the D-ornithyl methyl ester derivative of amphotericin B (SCH). In vitro studies showed that the Aspergillus isolate was equally susceptible to AMB and SCH. Both drugs were equally effective in prolonging survival after intravenous challenge with conidia of A. fumigatus. This was apparent when treatment was begun 24 h after challenge or delayed until mice were moribund; SCH appears to be as equally effective as AMB in treatment of murine aspergillosis.

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Year:  1984        PMID： 6364905

Source DB:  PubMed          Journal:  Am Rev Respir Dis        ISSN： 0003-0805


  25 in total

1.  Detection and measurement of fungal burden in a guinea pig model of invasive pulmonary aspergillosis by novel quantitative nested real-time PCR compared with galactomannan and (1,3)-β-D-glucan detection.

Authors:  Martina Lengerova; Iva Kocmanova; Zdenek Racil; Kristyna Hrncirova; Sarka Pospisilova; Jiri Mayer; Laura K Najvar; Nathan P Wiederhold; William R Kirkpatrick; Thomas F Patterson
Journal:  J Clin Microbiol       Date:  2011-12-21       Impact factor: 5.948

2.  Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis.

Authors:  W R Kirkpatrick; R K McAtee; A W Fothergill; M G Rinaldi; T F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

3.  Efficacy of SCH56592 in a rabbit model of invasive aspergillosis.

Authors:  W R Kirkpatrick; R K McAtee; A W Fothergill; D Loebenberg; M G Rinaldi; T F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

4.  Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B.

Authors:  D W Denning; P Warn
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

5.  In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester.

Authors:  G S Kobayashi; J R Little; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

6.  Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosis.

Authors:  William R Kirkpatrick; Sofia Perea; Brent J Coco; Thomas F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

7.  Model of recurrent pulmonary aspergillosis in rats.

Authors:  Y Niki; E M Bernard; F F Edwards; H J Schmitt; B Yu; D Armstrong
Journal:  J Clin Microbiol       Date:  1991-07       Impact factor: 5.948

8.  Comparative efficacy of amphotericin B colloidal dispersion and amphotericin B deoxycholate suspension in treatment of murine coccidioidomycosis.

Authors:  K V Clemons; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1991-09       Impact factor: 5.191

9.  Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis.

Authors:  J R Perfect; D T Durack
Journal:  Antimicrob Agents Chemother       Date:  1985-12       Impact factor: 5.191

10.  Comparative efficacies of amphotericin B lipid complex and amphotericin B deoxycholate suspension against murine blastomycosis.

Authors:  K V Clemons; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191
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