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Literature DB >> 9925548

An alternative animal model for comparison of treatments for cryptococcal meningitis.

Abstract

Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are an acceptable model for the study of central nervous system infection with C. neoformans.

Entities: Chemical Disease Species

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Year: 1999 PMID： 9925548 PMCID： PMC89093

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

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Authors: B I Restrepo; J Ahrens; J R Graybill
Journal: Antimicrob Agents Chemother Date: 1989-08 Impact factor: 5.191

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Authors: M J Humphrey; S Jevons; M H Tarbit
Journal: Antimicrob Agents Chemother Date: 1985-11 Impact factor: 5.191

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Authors: J Van Cutsem; F Van Gerven; P A Janssen
Journal: Rev Infect Dis Date: 1987 Jan-Feb

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Authors: E Palou de Fernandez; M M Patino; J R Graybill; M H Tarbit
Journal: J Antimicrob Chemother Date: 1986-08 Impact factor: 5.790

5. Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis.

Authors: J R Perfect; D T Durack
Journal: Antimicrob Agents Chemother Date: 1985-12 Impact factor: 5.191

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Authors: P C Craven; J R Graybill; J H Jorgensen
Journal: Am Rev Respir Dis Date: 1982-06

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Authors: J R Perfect; D T Durack
Journal: J Infect Dis Date: 1982-09 Impact factor: 5.226

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Authors: J R Graybill; J Ahrens
Journal: Sabouraudia Date: 1984

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Authors: M R Sneller; A Hariri; W G Sorenson; H W Larsh
Journal: Antimicrob Agents Chemother Date: 1977-09 Impact factor: 5.191

10. Host defense in cryptococcosis. III. Protection of nude mice by thymus transplantation.

Authors: J R Graybill; L Mitchell; D J Drutz
Journal: J Infect Dis Date: 1979-10 Impact factor: 5.226

4 in total

1. Phenotypic switching of Cryptococcus neoformans can produce variants that elicit increased intracranial pressure in a rat model of cryptococcal meningoencephalitis.

Authors: B C Fries; S C Lee; R Kennan; W Zhao; A Casadevall; D L Goldman
Journal: Infect Immun Date: 2005-03 Impact factor: 3.441