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Literature DB >> 1751456

Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.

W J Power¹, A Benedict-Smith, M Hillery, K Brady, L M Collum.

Abstract

The results of a randomised double-blind clinical trial of 0.1% bromovinyldeoxyuridine (BVDU) and 1% trifluorothymidine (TFT) in 60 patients with corneal dendritic ulceration are presented. There was no significant difference between BVDU and TFT in terms of numbers of ulcers healed (p = 0.61), mean healing time (p = 0.065), and cumulative healing rate (p = 0.058). No serious side effects were observed, though transient stinging was recorded in five patients receiving TFT and in three patients receiving BVDU. One patient in the group treated with TFT developed a punctate epitheliopathy.

Entities: Chemical Disease Species

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Year: 1991 PMID： 1751456 PMCID： PMC1042518 DOI： 10.1136/bjo.75.11.649

Source DB: PubMed Journal: Br J Ophthalmol ISSN： 0007-1161 Impact factor: 4.638

12 in total

Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.

1. Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers.

2. (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

3. Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.

4. Oral acyclovir (Zovirax) in herpes simplex dendritic corneal ulceration.

5. Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration.

6. (E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis.

7. Acyclovir (Zovirax) in herpetic disciform keratitis.

8. Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the topical treatment of herpes simplex keratitis.

9. Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells.

10. On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Review 1. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

2. ["Herpetic keratitis". Various expressions require different therapeutic approaches].

Review 3. Common ocular infections. A prescriber's guide.

4. In vitro synergism of trifluorothymidine and ganciclovir against HSV-1.

5. The treatment of herpes simplex virus epithelial keratitis.

Review 6. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.