Literature DB >> 2669938

Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.

O P van Bijsterveld1, P J Meurs, E de Clercq, P C Maudgal.   

Abstract

Bromovinyldeoxyuridine is a potent and safe antiherpes compound that in combination with a placebo treatment promoted the partial and complete healing of herpetic epithelial disease in 22 patients in average times of 4-6 days and 8.5 days respectively. However, when BVDU was combined with 1.5 X 10(6) IU of recombinant a 2C interferon, partial and complete healing times for keratitis in 19 patients were reduced to 2-6 days and 4-6 days respectively. No toxic effects of the medications were observed in any patient.

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Year:  1989        PMID： 2669938      PMCID： PMC1041826          DOI： 10.1136/bjo.73.8.604

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  19 in total

1.  Comparative evaluation of BVDU ((E)-5-(2-bromovinyl)-2'-deoxyuridine) in the treatment of experimental herpes simplex keratitis in rabbits.

Authors:  P C Maudgal; E De Clercq; J Descamps; L Missotten
Journal:  Bull Soc Belge Ophtalmol       Date:  1979

2.  Combination therapy of dendritic keratitis with trifluorothymidine and interferon.

Authors:  R Sundmacher; K Cantell; D Neumann-Haefelin
Journal:  Lancet       Date:  1978-09-23       Impact factor: 79.321

3.  Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins.

Authors:  Y C Cheng; G Dutschman; E De Clercq; A S Jones; S G Rahim; G Verhelst; R T Walker
Journal:  Mol Pharmacol       Date:  1981-07       Impact factor: 4.436

4.  Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus.

Authors:  E De Clercq; J Descamps; G Verhelst; R T Walker; A S Jones; P F Torrence; D Shugar
Journal:  J Infect Dis       Date:  1980-05       Impact factor: 5.226

Review 5.  Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs.

Authors:  E De Clercq; R T Walker
Journal:  Pharmacol Ther       Date:  1984       Impact factor: 12.310

6.  Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells.

Authors:  H S Allaudeen; M S Chen; J J Lee; E De Clercq; W H Prusoff
Journal:  J Biol Chem       Date:  1982-01-25       Impact factor: 5.157

7.  Experimental stroma herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine.

Authors:  P C Maudgal; E De Clercq; J Descamps; L Missotten; J Wijnhoven
Journal:  Arch Ophthalmol       Date:  1982-04

8.  Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the topical treatment of herpes simplex keratitis.

Authors:  P C Maudgal; L Missotten; E De Clercq; J Descamps; E De Meuter
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1981

9.  Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells.

Authors:  J Descamps; E De Clercq
Journal:  J Biol Chem       Date:  1981-06-25       Impact factor: 5.157

10.  On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Authors:  H S Allaudeen; J W Kozarich; J R Bertino; E De Clercq
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205
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  5 in total

Review 1.  Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Authors:  Kirk R Wilhelmus
Journal:  Cochrane Database Syst Rev       Date:  2015-01-09

Review 2.  Antidepressants in inflammatory bowel disease.

Authors:  Antonina Mikocka-Walus; Alexander C Ford; Douglas A Drossman
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2020-02-18       Impact factor: 46.802

3.  The treatment of herpes simplex virus epithelial keratitis.

Authors:  K R Wilhelmus
Journal:  Trans Am Ophthalmol Soc       Date:  2000

Review 4.  Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Authors:  Kirk R Wilhelmus
Journal:  Cochrane Database Syst Rev       Date:  2010-12-08

5.  Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.

Authors:  W J Power; A Benedict-Smith; M Hillery; K Brady; L M Collum
Journal:  Br J Ophthalmol       Date:  1991-11       Impact factor: 4.638
  5 in total

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