Literature DB >> 17505491

In vivo molecular imaging biomarkers: clinical pharmacology's new "PET"?

R Nutt1, L J Vento, M H T Ridinger.   

Abstract

Medicine, including the pharmaceutical and biotechnology industries as well as many clinical practitioners, has recognized the importance of using molecular imaging biomarkers, including those labeled in such a way as to be imaged by positron emission tomography (PET), as tools for predicting outcomes in drug development and creating opportunities for "personalized" medicine, for diagnosing early-stage disease, and for the follow-up of the effectiveness of treatment.(1) However, only one important and widely used PET biomarker is currently approved by the Food and Drug Administration (FDA). If the technology is so important, we can ask why there is such a limitation to the availability of these biomarkers.

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Year:  2007        PMID: 17505491     DOI: 10.1038/sj.clpt.6100213

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  11 in total

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4.  In vivo fluorescence lifetime imaging for monitoring the efficacy of the cancer treatment.

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6.  Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus.

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Review 7.  Biological imaging of atherosclerosis: moving beyond anatomy.

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8.  In vivo fluorescence lifetime imaging monitors binding of specific probes to cancer biomarkers.

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9.  In vivo assessment of HER2 receptor density in HER2-positive tumors by near-infrared imaging, using repeated injections of the fluorescent probe.

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Journal:  Technol Cancer Res Treat       Date:  2013-08-31

10.  Using in vivo fluorescence lifetime imaging to detect HER2-positive tumors.

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Journal:  EJNMMI Res       Date:  2018-04-04       Impact factor: 3.138

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