Literature DB >> 17504229

Demystifying the ACE polymorphism: from genetics to biology.

Raquel Castellon1, Hamdi K Hamdi.   

Abstract

The angiotensin converting enzyme (ACE) I/D polymorphism has been one of the most studied genetic systems. It comprises hundreds of reports and a myriad of disease associations, including cardiovascular, metabolic, immune, cancer, aging, neurodegenerative and psychiatric diseases. Despite the wealth of information on the ACE polymorphism and the well-known functions of ACE, several questions arise. Why does the ACE polymorphism associate with so many diseases? What is its function? In this review, we summarize the current information on the ACE polymorphism and explain its function in the context of cell survival. We also provide a model to understand its role in biology and disease at the organism and population levels.

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Year:  2007        PMID： 17504229     DOI： 10.2174/138161207780618902

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  15 in total

1.  The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.

Authors:  Feng Liu; Jennifer Havens; Qi Yu; Gang Wang; Robin L Davisson; Virginia M Pickel; Costantino Iadecola
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2012-02-15

2.  Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review.

Authors:  Paul R Gard
Journal:  Int J Mol Epidemiol Genet       Date:  2010-03-20

3.  Lack of association of genetic polymorphisms of angiotensin converting enzyme 1 and angiotensin II type 1 receptor with breast cancer risk in Iranian population.

Authors:  Soha Namazi; Ahmad Monabati; Shirin Ardeshir-Rouhani-Fard; Negar Azarpira
Journal:  Tumour Biol       Date:  2013-05-23

4.  PharmGKB summary: very important pharmacogene information for angiotensin-converting enzyme.

Authors:  Caroline F Thorn; Teri E Klein; Russ B Altman
Journal:  Pharmacogenet Genomics       Date:  2010-02       Impact factor: 2.089

5.  IFITM3, FURIN, ACE1, and TNF-α Genetic Association With COVID-19 Outcomes: Systematic Review and Meta-Analysis.

Authors:  João Locke Ferreira de Araújo; Diego Menezes; Renato Santana de Aguiar; Renan Pedra de Souza
Journal:  Front Genet       Date:  2022-04-01       Impact factor: 4.599

6.  Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus.

Authors:  S Merlo; J Novák; N Tkáčová; J Nikolajević Starčević; M Šantl Letonja; J Makuc; A Cokan Vujkovac; J Letonja; D Bregar; M Zorc; M Rojko; S Mankoč; P Kruzliak; D Petrovič
Journal:  Balkan J Med Genet       Date:  2016-07-09       Impact factor: 0.519

7.  Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Authors:  Mary F Feitosa; Aldi T Kraja; Daniel I Chasman; Yun J Sung; Thomas W Winkler; Ioanna Ntalla; Xiuqing Guo; Nora Franceschini; Ching-Yu Cheng; Xueling Sim; Dina Vojinovic; Jonathan Marten; Solomon K Musani; Changwei Li; Amy R Bentley; Michael R Brown; Karen Schwander; Melissa A Richard; Raymond Noordam; Hugues Aschard; Traci M Bartz; Lawrence F Bielak; Rajkumar Dorajoo; Virginia Fisher; Fernando P Hartwig; Andrea R V R Horimoto; Kurt K Lohman; Alisa K Manning; Tuomo Rankinen; Albert V Smith; Salman M Tajuddin; Mary K Wojczynski; Maris Alver; Mathilde Boissel; Qiuyin Cai; Archie Campbell; Jin Fang Chai; Xu Chen; Jasmin Divers; Chuan Gao; Anuj Goel; Yanick Hagemeijer; Sarah E Harris; Meian He; Fang-Chi Hsu; Anne U Jackson; Mika Kähönen; Anuradhani Kasturiratne; Pirjo Komulainen; Brigitte Kühnel; Federica Laguzzi; Jian'an Luan; Nana Matoba; Ilja M Nolte; Sandosh Padmanabhan; Muhammad Riaz; Rico Rueedi; Antonietta Robino; M Abdullah Said; Robert A Scott; Tamar Sofer; Alena Stančáková; Fumihiko Takeuchi; Bamidele O Tayo; Peter J van der Most; Tibor V Varga; Veronique Vitart; Yajuan Wang; Erin B Ware; Helen R Warren; Stefan Weiss; Wanqing Wen; Lisa R Yanek; Weihua Zhang; Jing Hua Zhao; Saima Afaq; Najaf Amin; Marzyeh Amini; Dan E Arking; Tin Aung; Eric Boerwinkle; Ingrid Borecki; Ulrich Broeckel; Morris Brown; Marco Brumat; Gregory L Burke; Mickaël Canouil; Aravinda Chakravarti; Sabanayagam Charumathi; Yii-Der Ida Chen; John M Connell; Adolfo Correa; Lisa de Las Fuentes; Renée de Mutsert; H Janaka de Silva; Xuan Deng; Jingzhong Ding; Qing Duan; Charles B Eaton; Georg Ehret; Ruben N Eppinga; Evangelos Evangelou; Jessica D Faul; Stephan B Felix; Nita G Forouhi; Terrence Forrester; Oscar H Franco; Yechiel Friedlander; Ilaria Gandin; He Gao; Mohsen Ghanbari; Bruna Gigante; C Charles Gu; Dongfeng Gu; Saskia P Hagenaars; Göran Hallmans; Tamara B Harris; Jiang He; Sami Heikkinen; Chew-Kiat Heng; Makoto Hirata; Barbara V Howard; M Arfan Ikram; Ulrich John; Tomohiro Katsuya; Chiea Chuen Khor; Tuomas O Kilpeläinen; Woon-Puay Koh; José E Krieger; Stephen B Kritchevsky; Michiaki Kubo; Johanna Kuusisto; Timo A Lakka; Carl D Langefeld; Claudia Langenberg; Lenore J Launer; Benjamin Lehne; Cora E Lewis; Yize Li; Shiow Lin; Jianjun Liu; Jingmin Liu; Marie Loh; Tin Louie; Reedik Mägi; Colin A McKenzie; Thomas Meitinger; Andres Metspalu; Yuri Milaneschi; Lili Milani; Karen L Mohlke; Yukihide Momozawa; Mike A Nalls; Christopher P Nelson; Nona Sotoodehnia; Jill M Norris; Jeff R O'Connell; Nicholette D Palmer; Thomas Perls; Nancy L Pedersen; Annette Peters; Patricia A Peyser; Neil Poulter; Leslie J Raffel; Olli T Raitakari; Kathryn Roll; Lynda M Rose; Frits R Rosendaal; Jerome I Rotter; Carsten O Schmidt; Pamela J Schreiner; Nicole Schupf; William R Scott; Peter S Sever; Yuan Shi; Stephen Sidney; Mario Sims; Colleen M Sitlani; Jennifer A Smith; Harold Snieder; John M Starr; Konstantin Strauch; Heather M Stringham; Nicholas Y Q Tan; Hua Tang; Kent D Taylor; Yik Ying Teo; Yih Chung Tham; Stephen T Turner; André G Uitterlinden; Peter Vollenweider; Melanie Waldenberger; Lihua Wang; Ya Xing Wang; Wen Bin Wei; Christine Williams; Jie Yao; Caizheng Yu; Jian-Min Yuan; Wei Zhao; Alan B Zonderman; Diane M Becker; Michael Boehnke; Donald W Bowden; John C Chambers; Ian J Deary; Tõnu Esko; Martin Farrall; Paul W Franks; Barry I Freedman; Philippe Froguel; Paolo Gasparini; Christian Gieger; Jost Bruno Jonas; Yoichiro Kamatani; Norihiro Kato; Jaspal S Kooner; Zoltán Kutalik; Markku Laakso; Cathy C Laurie; Karin Leander; Terho Lehtimäki; Lifelines Cohort Study; Patrik K E Magnusson; Albertine J Oldehinkel; Brenda W J H Penninx; Ozren Polasek; David J Porteous; Rainer Rauramaa; Nilesh J Samani; James Scott; Xiao-Ou Shu; Pim van der Harst; Lynne E Wagenknecht; Nicholas J Wareham; Hugh Watkins; David R Weir; Ananda R Wickremasinghe; Tangchun Wu; Wei Zheng; Claude Bouchard; Kaare Christensen; Michele K Evans; Vilmundur Gudnason; Bernardo L Horta; Sharon L R Kardia; Yongmei Liu; Alexandre C Pereira; Bruce M Psaty; Paul M Ridker; Rob M van Dam; W James Gauderman; Xiaofeng Zhu; Dennis O Mook-Kanamori; Myriam Fornage; Charles N Rotimi; L Adrienne Cupples; Tanika N Kelly; Ervin R Fox; Caroline Hayward; Cornelia M van Duijn; E Shyong Tai; Tien Yin Wong; Charles Kooperberg; Walter Palmas; Kenneth Rice; Alanna C Morrison; Paul Elliott; Mark J Caulfield; Patricia B Munroe; Dabeeru C Rao; Michael A Province; Daniel Levy
Journal:  PLoS One       Date:  2018-06-18       Impact factor: 3.240

8.  Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch-Schönlein purpura: a meta-analysis.

Authors:  Xiaoqing Zhang; Lin Wu; Minglei Chai; Xiaofang Huang; Jiajin Zhu; Shaojun Li; Jun Zhang; Huahong Zhang
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2019 Jan-Mar       Impact factor: 1.636

9.  Multi-species comparative analysis of the equine ACE gene identifies a highly conserved potential transcription factor binding site in intron 16.

Authors:  Natasha A Hamilton; Imke Tammen; Herman W Raadsma
Journal:  PLoS One       Date:  2013-02-08       Impact factor: 3.240

10.  Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Kawasaki disease: a meta-analysis.

Authors:  Yan Pan; Hongzhu Lu
Journal:  Afr Health Sci       Date:  2017-12       Impact factor: 0.927
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